Brand Names

How to Use

When you take leucovorin :

• Leucovorin must be taken with trimetrexate to help prevent very serious, possibly life-threatening, unwanted side effects. Leucovorin must be taken during trimetrexate treat and for 3 days after trimetrexate is stopped. The best for you to take this drug exactly as your family doctor told you. Failure to do this can result in very serious side effects.
• Take oral leucovorin exactly as directed by your family doctor . Do not take more of it, do not take it more often and do not take it for a longer time than your family doctor ordered. Always do not stop taking this drug without checking with your family doctor first.
• Oral leucovorin works best when there is a constant amount in the blood To help keep the amount constant, do not miss any doses . If you need help in planning the best times to take your drug, check with your health care professional.
• If you vomit shortly after taking an oral dose of leucovorin, check with your family doctor. You will be told whether to take the dose again or to wait until the next scheduled dose.

Dosage

For trimetrexate
• For the treat of Pneumocystis carinii pneumonia:
  • For injection dosage form:
    • Adults 45 milligrams per square meter of body surface area - mg/m injected into a vein once a day for twenty-one days. Your family doctor will check your blood counts and may change your dose based on these counts. Your family doctor may want to give you a dose you based on how much you weigh. Your dose will be determined by your family doctor.
    • Children and teenagers Use and dose must be determined by your family doctor.

For leucovorin
• For the prevention of serious side effects of trimetrexate in the treat of Pneumocystis carinii pneumonia:
  • For the oral or injection dosage forms:
    • Adults 20 milligrams per square meter of body surface area - mg/m taken by mouth or injected into a vein every six hours for twenty-four days. Your family doctor will check your blood counts and may change your dose based on these counts. Your family doctor may want to give you a dose you based on how much you weigh. Your dose will be determined by your family doctor.
    • Children and teenagers Use and dose must be determined by your family doctor.

Missed dose If you miss a dose of leucovorin, take it as soon as possible. This will help to keep a constant amount of drug in the blood. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage To store leucovorin:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the drug to break down.
• Do not keep outdated drug or drug no longer needed. Be sure that any discarded drug is out of the reach of children.