Trimetrexate - Systemic
Brand Names
Neutrexin
Trimetrexate *** Before Using *** How to Use *** Side Effects *** Additional Information
Before Using This Medication
In deciding to using a medication, the problems of uses this drugs must be
weighed against the good it will do. This is a decision you
will make. For trimetrexate, the following must be considered
Allergic reaction
Tell your family doctor if you have any unusual or
allergy to trimetrexate, methotrexate, or leucovorin. Also tell
your health care professional if you are allergic to any other substances,
such as foods, preservatives, or dyes.
Pregnancy care
Use of trimetrexate during pregnancy must be avoided
whenever possible since trimetrexate has causing birth defects and death of
the fetus in animal studies. The use of birth control is recommended during
trimetrexate therapy. Tell your family doctor immediately if you think you may be
pregnant or if you need advice about birth control.
Breast-feeding problem
It is not known if trimetrexate passes into breast
milk. However, breast-feeding must be stopped during treat with this
drug because trimetrexate may cause serious unwanted effects in nursing
babies.
Use for Children
This drug has been tested in a limited number
of children younger than 18 years of age. Trimetrexate can cause serious side
effects in any patient. However, in effective doses, this drug did not
cause various side effects or problems in the few children who received
it than it does in adults.
Elderly care
Many medication have not been studied specifically
in elderly people. Therefore, it may not be known whether they work exactly
the same way they do in adults people or if they cause various side effects
or problems in elderly people. There is no special info comparing use
of trimetrexate in the elderly with use in other age groups.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When you are taking
trimetrexate, it is especially important that your health care professional
know if you are taking any of the following:
-
Acetaminophen - Tylenol - with long-term, high-dose use
-
Amiodarone - Cordarone
-
Anabolic steroids - nandrolone " Anabolin ", oxandrolone "
Anavar ", oxymetholone " Anadrol ", stanozolol " Winstrol "
-
Androgens - male hormones
-
Carbamazepine - Tegretol
-
Chloroquine - Aralen
-
Dantrolene - Dantrium
-
Daunorubicin - Cerubidine
-
Estrogens - female hormones
-
Etretinate - Tegison
-
Hydroxychloroquine - Plaquenil
-
Methyldopa - Aldomet
-
Naltrexone - Trexan - with long-term, high-dose use
-
Phenothiazines - acetophenazine " Tindal ", chlorpromazine "
Thorazine ", fluphenazine " Prolixin ", mesoridazine " Serentil ",
perphenazine " Trilafon ", prochlorperazine " Compazine ", promazine
" Sparine ", promethazine " Phenergan ", thioridazine " Mellaril ",
trifluoperazine " Stelazine ", triflupromazine " Vesprin ", trimeprazine
" Temaril "
-
Phenytoin - Dilantin Use of these medication while you
are taking trimetrexate may decrease the breakdown of trimetrexate in the
liver and increase the risk of trimetrexate side effects
-
Alcohol
-
Cimetidine - Tagamet
-
Diltiazem - Cardizem
-
Erythromycins - drug for infection
-
Isoniazid - INH, Nydrazid
-
Quinine - Quinamm
-
Ranitidine - Zantac
-
Verapamil - Calan Use of these medication with trimetrexate
may increase the risk of trimetrexate side effects
-
Amphotericin B by injection - Fungizone
-
Antineoplastics - cancer drug
-
Azathioprine - Imuran
-
Colchicine
-
Cyclophosphamide - Cytoxan
-
Flucytosine - Ancobon
-
Ganciclovir - Cytovene
-
Interferon - Intron A, Roferon-A
-
Zidovudine - AZT, Retrovir Receiving trimetrexate while
you are using these medication may make side effects effecting the blood worse
-
Cisplatin - Platinol
-
Combination pain drug containing acetaminophen and aspirin -
Excedrin or other salicylates - with large amounts taken regularly
-
Cyclosporine - Sandimmune
-
Deferoxamine - Desferal - with long-term use
-
Foscarnet - Foscavir
-
Inflammation or pain drug - except narcotics
-
Lithium - Lithane
-
Penicillamine - Cuprimine
-
Streptozocin - Zanosar
-
Tiopronin - Thiola Use of these medication while you are
taking trimetrexate may decrease the elimination of trimetrexate through the
kidneys and increase the risk of trimetrexate toxicity
-
Antithyroid agents - drug for overactive thyroid
-
Carmustine - BiCNU
-
Chloramphenicol - Chloromycetin
-
Disulfiram - Antabuse
-
Divalproex - Depakote
-
Gold salts - drug for arthritis
-
Mercaptopurine - Purinethol
-
Methotrexate - Mexate
-
Oral contraceptives - birth control pills containing estrogen
-
Other anti-infectives - drug for infection by mouth or by injection
-
Plicamycin - Mithracin
-
Valproic acid - Depakene Use of these medication with
trimetrexate may increase the risk of side effects from trimetrexate
Other Information for using
The presence of other medical
problems may effect the use of trimetrexate. Make sure you tell your family doctor
if you have any other medical problems, especially:
-
Anemia
-
Blood problems
-
Low platelet count
-
Low white blood cell count Trimetrexate may make any blood
diseases that you have worse
-
Mouth ulcers or other mouth sores
-
Stomach ulcer or other stomach or intestinal problems Trimetrexate
may make these conditions that you have worse
-
Kidney disease
-
Liver disease Kidney or liver disease may increase the risk
of side effects from trimetrexate
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