Thrombolytic Agents : Before Using

Thrombolytic Agents - Systemic

Thrombolytic Agents *** Before Using *** How to Use *** Fore Safe Use *** Side Effects *** Additional Information

Before Using This Medication

In deciding to using a medication, the problems of uses this drugs must be weighed against the good it will do. This is a decision you will make. For thrombolytic agents, the following must be considered

Allergic reaction

Tell your family doctor if you have any unusual or allergy to alteplase, anistreplase, streptokinase, or urokinase. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy care

Tell your family doctor if you are pregnant or if you have recently had a baby.

There is a slight risk that use of a thrombolytic agent during the first five months of pregnancy may cause a miscarriage. However, both streptokinase and urokinase have been using in pregnant women and have not been reported to cause this problem. Always studies in pregnant women - for streptokinase and studies in pets - for urokinase have not shown that these medication cause either miscarriage or harm to the fetus - including birth defects. Studies on birth defects with alteplase and anistreplase have not been done in either pregnant women or pets.

Breast-feeding problem

It is not known whether thrombolytic agents pass into the breast milk. Although most medication pass into breast milk in small amounts, many of them may be using safely while breast-feeding. Mothers who are taking any of these medication and who wish to breast-feed must discuss this with their family doctor.

Use for Children

Studies on these medication have been done only in adult diseaseds and there is no special info comparing the use of thrombolytic agents in child with use in other age groups. However, streptokinase has occasionally been using in child to dissolve blood clots in certain blood vessels. Bleeding may be more likely to occur in child, who are usually more sensitive than adults to the effects of streptokinase.

Elderly care

The need for treat with a thrombolytic agent - instead of other kinds of treat may be increased in elderly diseaseds with blood clots. However, the risk of bleeding may also be increased. It is especially important that you discuss the use of this drug with your family doctor.

Drug interactions

Although certain medication must not be using together at all, in other cases two various medication may be using together even if an interaction might occur. In these cases, your family doctor may want to change the dose, or other precautions may be necessary. Before you receive a thrombolytic agent, it is especially important that your family doctor know if you are taking any of the following:

Anticoagulants - blood thinners
Aspirin
Cefamandole - Mandol
Cefoperazone - Cefobid
Cefotetan - Cefotan
Dipyridamole - Persantine
Divalproex - Depakote
Enoxaparin - Lovenox
Heparin
Indomethacin - Indocin
Inflammation or pain drug - except narcotics
Phenylbutazone - Butazolidin
Plicamycin - Mithracin
Sulfinpyrazone - Anturane
Thrombolytic agents, other
Ticlopidine - Ticlid
Valproic acid - Depakene The risk of bleeding may be increased

Always tell your family doctor if you have had an injection of anistreplase or streptokinase within the past year. If you have, these medication may not work properly if they are given to you again. Your family doctor may decide to use alteplase or urokinase instead.

Other Information for using

The presence of other medical problems or recent delivery of a child may effect the use of thrombolytic agents. Make sure you tell your family doctor if you have any other medical problems, especially:

Allergic reaction to streptokinase, anistreplase, or urokinase - or history of Increased risk of an allergy
Blood disease, bleeding problems, or a history of bleeding in any part of the body
Brain disease or tumor
Heart or blood vessel disease, including irregular heartbeat
High blood pressure
Liver disease - severe
Stroke, especially with seizure - or history of The risk of serious bleeding may be increased

Streptococcal - “strep” infection - recent
Surgery within the last two months Anistreplase or streptokinase may not work properly after a streptococcal infection; your family doctor may decide to use a various thrombolytic agent

Always tell your family doctor if you have recently had any of the following conditions:

Falls or blows to the body or head or any other injury
Injections into a blood vessel
Placement of any tube into the body
Surgery, including dental surgery The risk of serious bleeding may be increased

If you have recently had a baby, use of these medication may cause serious bleeding.