Sulfonamides and Trimethoprim - Systemic
Sulfonamides and Trimethoprim *** Before Using *** How to Use *** Fore Safe Use *** Side Effects *** Additional Information
Before Using
In deciding to using a medication,
the chance of taking the drug must be weighed against the good it will
do. This is a decision you will make. For sulfonamide and
trimethoprim combinations, the following must be considered
Allergic reaction
Tell your family doctor if you have any unusual or
allergy to sulfa medication, furosemide - Lasix or thiazide
diuretics - water pills, oral antidiabetics - diabetes drug you take by
mouth, glaucoma drug you take by mouth - for example, acetazolamide "
Diamox ", dichlorphenamide " Daranide ", methazolamide " Neptazane ",
or trimethoprim - Trimpex. Also tell your health care professional if
you are allergic to any other substances, such as foods, preservatives -
sulfites, or dyes.
Pregnancy care
Sulfamethoxazole and trimethoprim combination has
not been reported to cause birth defects or other problems. However,
studies in mice, rats and rabbits have shown that some sulfonamides cause
birth defects, including cleft palate and bone problems. Studies in rabbits
have also shown that trimethoprim causes birth defects, as well as a decrease
in the number of successful pregnancies. Sulfonamides are not recommended
for use at the time of labor and delivery because these medication may cause
unwanted effects in the baby.
Breast-feeding problem
Sulfonamides and trimethoprim pass into the breast
milk. These medication are not recommended for use during breast-feeding. They
may cause liver problems, anemia and other unwanted effects in nursing babies,
especially those with glucose-6-phosphate dehydrogenase - G6PD deficiency.
Use for Children
Sulfadiazine and trimethoprim combination must
not be given to infants less than 3 months of age. Sulfamethoxazole and trimethoprim
combination must not be given to infants less than 2 months of age unless
directed by the child's family doctor. These combinations may cause unwanted effects.
In special situations, sulfamethoxazole and trimethoprim combination may be
given to infants less than 2 months of age.
Elderly care
Elderly people are especially sensitive to the effects
of sulfonamide and trimethoprim combinations. Severe skin problems and blood
problems may be more likely to occur in the elderly. These problems may also
be more likely to occur in diseaseds who are taking diuretics - water pills
along with this drug.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When you are taking
sulfonamide and trimethoprim combinations, it is especially important that
your health care professional know if you are taking any of the following:
-
Acetaminophen - Tylenol - with long-term, high-dose use
-
Amiodarone - Cordarone
-
Anabolic steroids - nandrolone " Anabolin ", oxandrolone "
Anavar ", oxymetholone " Anadrol ", stanozolol " Winstrol "
-
Androgens - male hormones
-
Antithyroid agents - drug for overactive thyroid
-
Carbamazepine - Tegretol
-
Carmustine - BiCNU
-
Chloroquine - Aralen
-
Dantrolene - Dantrium
-
Daunorubicin - Cerubidine
-
Disulfiram - Antabuse
-
Divalproex - Depakote
-
Estrogens - female hormones
-
Etretinate - Tegison
-
Gold salts - drug for arthritis
-
Mercaptopurine - Purinethol
-
Naltrexone - Trexan - with long-term, high-dose use
-
Oral contraceptives - birth control pills containing estrogens
-
Other anti-infectives by mouth or by injection - drug for infection
-
Phenothiazines - acetophenazine " Tindal ", chlorpromazine "
Thorazine ", fluphenazine " Prolixin ", mesoridazine " Serentil ",
perphenazine " Trilafon ", prochlorperazine " Compazine ", promazine
" Sparine ", promethazine " Phenergan ", thioridazine " Mellaril ",
trifluoperazine " Stelazine ", triflupromazine " Vesprin ", trimeprazine
" Temaril "
-
Plicamycin - Mithracin
-
Valproic acid - Depakene Use of sulfonamide and trimethoprim
combinations with these medication may increase the risk of side effects
effecting the liver
-
Acetohydroxamic acid - Lithostat
-
Furazolidone - Furoxone
-
Nitrofurantoin - Furadantin
-
Primaquine
-
Procainamide - Pronestyl
-
Quinidine - Quinidex
-
Quinine - Quinamm
-
Sulfoxone - Diasone Use of sulfonamide and trimethoprim
combinations with these medication may increase the risk of side effects
effecting the blood
-
Anticoagulants - blood thinners
-
Digoxin - Lanoxin
-
Ethotoin - Peganone
-
Mephenytoin - Mesantoin
-
Methotrexate - Mexate
-
Phenytoin - Dilantin Use of sulfonamide and trimethoprim
combinations with these medication may increase the risk of side effects
of these medication
-
Antidiabetics, oral - diabetes drug you take by mouth Use
of oral antidiabetics with sulfonamide and trimethoprim combinations may increase
the risk of side effects effecting the blood andthe side effects of
the oral antidiabetics
-
Methenamine - Mandelamine Use of methenamine with sulfonamide
and trimethoprim combinations may increase the risk of side effects of the
sulfonamide
-
Methyldopa - Aldomet Use of methyldopa with sulfonamide
and trimethoprim combinations may increase the risk of side effects effecting
the liver andthe blood
Other Information for using
The presence of other medical
problems may effect the use of sulfonamide and trimethoprim combinations.
Make sure you tell your family doctor if you have any other medical problems, especially:
-
Anemia or other blood problems
-
Glucose-6-phosphate dehydrogenase - G6PD deficiency Patients
with these problems may have an increase in side effects effecting the blood
-
Kidney disease
-
Liver disease Patients with kidney andliver disease may
have an increased risk of side effects
-
Porphyria This drug may bring on an attack of porphyria
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