Sulfadoxine and Pyrimethamine : Before Using

Sulfadoxine and Pyrimethamine - Systemic

Brand Names

Fansidar Sulfadoxine and Pyrimethamine *** Before Using *** How to Use *** Fore Safe Use *** Side Effects *** Additional Information

Before Using

In deciding to using a medication, the chance of taking the drug must be weighed against the good it will do. This is a decision you will make. For sulfadoxine and pyrimethamine combination, the following must be considered

Allergic reaction

Tell your family doctor if you have any unusual or allergy to sulfa medication, furosemide - Lasix or thiazide diuretics - water pills, oral antidiabetics - diabetes drug you take by mouth, glaucoma drug you take by mouth - acetazolamide " Diamox ", dichlorphenamide " Daranide ", methazolamide " Neptazane ", or pyrimethamine - Daraprim. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy care

Studies have not been done in pregnant women. However, use is not recommended during pregnancy. Studies in rats have shown that sulfadoxine and pyrimethamine combination may cause birth defects and anemia. Always women who travel to an area where there is a risk of getting malaria and who may be taking sulfadoxine and pyrimethamine combination, must avoid becoming pregnant.

Breast-feeding problem

Sulfadoxine and pyrimethamine pass into the breast milk. This drug is not recommended for use during breast-feeding. It may cause liver problems, anemia and other unwanted effects in nursing babies.

Use for Children

Sulfadoxine and pyrimethamine combination must not be using in infants up to 2 months of age.

Elderly care

Many medication have not been studied specifically in elderly people. Therefore, it may not be known whether they work exactly the same way they do in adults people or if they cause various side effects or problems in elderly people. There is no special info comparing use of sulfadoxine and pyrimethamine combination in the elderly with use in other age groups.

Drug interactions

Although certain medication must not be using together at all, in other cases two various medication may be using together even if an interaction might occur. In these cases, your family doctor may want to change the dose, or other precautions may be necessary. When you are taking sulfadoxine and pyrimethamine combination, it is especially important that your health care professional know if you are taking any of the following:

Acetaminophen - Tylenol - with long-term, high-dose use
Amiodarone - Cordarone
Anabolic steroids - nandrolone " Anabolin ", oxandrolone " Anavar ", oxymetholone " Anadrol ", stanozolol " Winstrol "
Androgens - male hormones
Carbamazepine - Tegretol
Carmustine - BiCNU
Chloroquine - Aralen
Dantrolene - Dantrium
Daunorubicin - Cerubidine
Disulfiram - Antabuse
Divalproex - Depakote
Estrogens - female hormones
Etretinate - Tegison
Gold salts - drug for arthritis
Hydroxychloroquine - Plaquenil
Naltrexone - Trexan - with long-term, high-dose use
Oral contraceptives - birth control pills containing estrogen
Other anti-infectives by mouth or by injection - drug for infection
Phenothiazines - acetophenazine " Tindal ", chlorpromazine " Thorazine ", fluphenazine " Prolixin ", mesoridazine " Serentil ", perphenazine " Trilafon ", prochlorperazine " Compazine ", promazine " Sparine ", promethazine " Phenergan ", thioridazine " Mellaril ", trifluoperazine " Stelazine ", triflupromazine " Vesprin ", trimeprazine " Temaril "
Phenytoin - Dilantin
Valproic acid - Depakene Use of sulfadoxine and pyrimethamine combination with these medication may increase the risk of side effects effecting the liver

Acetohydroxamic acid - Lithostat
Amphotericin B by injection - Fungizone
Antineoplastics - cancer medication
Azathioprine - Imuran
Chloramphenicol - Chloromycetin
Colchicine
Cyclophosphamide - Cytoxan
Dapsone
Flucytosine - Ancobon
Furazolidone - Furoxone
Ganciclovir - Cytovene
Interferon - Intron A, Roferon-A
Nitrofurantoin - Furadantin
Primaquine
Procainamide - Pronestyl
Quinidine - Quinidex
Quinine
Sulfoxone - Diasone
Vitamin K - AquaMEPHYTON, Synkayvite
Zidovudine - AZT, Retrovir Use of sulfadoxine and pyrimethamine combination with these medication may increase the risk of side effects effecting the blood

Antithyroid agents - drug for overactive thyroid
Mercaptopurine - Purinethol
Methotrexate - Mexate
Methyldopa - Aldomet
Plicamycin - Mithracin Use of sulfadoxine and pyrimethamine combination with these medication may increase the risk of side effects effecting the liver and the blood

Other Information for using

The presence of other medical problems may effect the use of sulfadoxine and pyrimethamine combination. Make sure you tell your family doctor if you have any other medical problems, especially:

Anemia or other blood problems Patients with these problems may have an increase in side effects involving the blood

Kidney disease
Liver disease Patients with kidney andliver disease may have an increased risk of side effects

Porphyria This drug may cause an attack of porphyria

Seizure disorders, such as epilepsy High doses of this drug may increase the risk of convulsions - seizures