Sirolimus : Before Using - rapamycin, Rapamune

Sirolimus - Systemic

Brand Names

rapamycin, Rapamune Sirolimus *** Before Using *** How to Use *** Fore Safe Use *** Side Effects

Before Using

In deciding to using a medication, the chance of taking the drug must be weighed against the good it will do. This is a decision you will make. For sirolimus, the following must be considered

Allergic reaction

Tell your family doctor if you have any unusual or allergic reaction to sirolimus. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy care

Sirolimus has not been studied in pregnant women. However, studies in pets have shown that sirolimus causes problems in the fetus. The best for you that an effective form of birth control be using before starting sirolimus therapy, during sirolimus therapy and for 12 weeks after sirolimus therapy has stopped.

Breast-feeding problem

It is not known whether sirolimus passes into human breast milk. However, because this drug may cause serious side effects, breast-feeding may not be recommended while you are receiving it. Discuss with your family doctor whether or not you must breast-feed while you are receiving sirolimus.

Drug interactions

Although certain medication must not be using together at all, in other cases two various medication may be using together even if an interaction might occur. In these cases, your family doctor may want to change the dose, or other precautions may be necessary. When you are taking sirolimus, it is especially important that your health care professional knows if you are taking any of the following:

Cyclosporine - e.g. Neoral or Sandimmune
Diltiazem - e.g. Cardizem
Ketoconazole - e.g. Nizoral May increase the effects of sirolimus by increasing the amount of this drug in the body

Rifampin - e.g. Rifadin
St. John's wort May decrease the effects of sirolimus by decreasing the amount of sirolimus in the body

Tacrolimus - e.g. Prograf May cause liver transplant rejection or serious side effects in diseaseds on sirolimus

Other Information for using

The presence of other medical problems may effect the use of sirolimus. Make sure you tell your family doctor if you have any other medical problems, especially:

Cancer
Hyperlipidemia - high amount of cholesterol and fats in the blood Sirolimus can make these conditions worse

Chickenpox - including recent exposure
Herpes zoster - shingles chance of severe disease effecting other parts of the body

Infection Sirolimus decreases the body's ability to fight infection

Liver disease A lower dose of sirolimus may be needed in diseaseds with this condition
Liver transplantation Sirolimus is not recommended in liver transplant diseaseds