Rifampin, Isoniazid, Pyrazinamide and Ethambutol - Systemic
Rifampin, Isoniazid, Pyrazinamide and Ethambutol *** Before Using *** How to Use *** Fore Safe Use *** Side Effects
Before Using
In deciding to using a medication,
the chance of taking the drug must be weighed against the good it will
do. This is a decision you will make. For rifampin, isoniazid,
pyrazinamide and ethambutol combination, the following must be considered
Allergic reaction
Tell your family doctor if you have any unusual
or allergy to ethionamide - Trecator-SC, pyrazinamide, niacin
- Nicobid, nicotinic acid, rifampin - Rifadin, rifabutin -
Mycobutin, rifapentine - Priftin, isoniazid - INH, Nydrazid,
or ethambutol - Myambutol. Also tell your health care professional if
you are allergic to any other substances, such as foods, preservatives, or
dyes.
Pregnancy care
Pregnant women with tuberculosis - TB must be
treated with TB medication, including rifampin, isoniazid, pyrazinamide and
ethambutol. Rifampin, isoniazid, pyrazinamide and ethambutol combination
has not been shown to cause birth defects or other problems. However,
rifampin can rarely cause bleeding in newborn babies and mothers when taken
during the last weeks of pregnancy. Always studies in rats and mice have shown
that rifampin given in high doses causes birth defects, usually backbone problems
- spina bifida and cleft palate.
Breast-feeding problem
Rifampin, isoniazid, pyrazinamide and ethambutol
pass into the breast milk. However, rifampin, isoniazid, pyrazinamide and
ethambutol have not been reported to cause problems in nursing babies.
Use for Children
Rifampin, isoniazid, pyrazinamide and ethambutol
combination may not be appropriate for use in child weighing under 30 kilograms
- kg - 66 pounds.
Elderly care
Liver problems are more likely to occur in diseaseds
over 50 years of age who are taking isoniazid-containing medication.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When you are taking
rifampin, isoniazid, pyrazinamide and ethambutol combination, it is especially
important that your health care professional know if you are taking any of
the following:
-
Acetaminophen - Tylenol - with long-term, high-dose use
-
Alfentanil - Alfenta
-
Amiodarone - Cordarone
-
Anabolic steroids - nandrolone " Anabolin ", oxandrolone "
Anavar ", oxymetholone " Anadrol ", stanozolol " Winstrol "
-
Androgens - male hormones
-
Antithyroid agents - drug for overactive thyroid
-
Carbamazepine - Tegretol
-
Carmustine - BiCNU
-
Chloroquine - Aralen
-
Dantrolene - Dantrium
-
Daunorubicin - Cerubidine
-
Divalproex - Depakote
-
Etretinate - Tegison
-
Gold salts - drug for arthritis
-
Hydroxychloroquine - Plaquenil
-
Mercaptopurine - Purinethol
-
Methyldopa - Aldomet
-
Naltrexone - Trexan - with long-term, high-dose use
-
Phenothiazines - acetophenazine " Tindal ", chlorpromazine "
Thorazine ", fluphenazine " Prolixin ", mesoridazine " Serentil ",
perphenazine " Trilafon ", prochlorperazine " Compazine ", promazine
" Sparine ", promethazine " Phenergan ", thioridazine " Mellaril ",
trifluoperazine " Stelazine ", triflupromazine " Vesprin ", trimeprazine
" Temaril "
-
Plicamycin - Mithracin
-
Valproic acid - Depakene These medication may increase
the risk of liver damage if taken with rifampin, isoniazid and pyrazinamide
combination
-
Aminophylline - Somophyllin
-
Amprenavir - Agenerase
-
Anticoagulants - blood thinners
-
Antidiabetics, oral - diabetes medication you take by mouth
-
Chloramphenicol
-
Corticosteroids - cortisone-like drug
-
Delavirdine - Rescriptor
-
Digitalis glycosides - heart drug
-
Disopyramide - Norpace
-
Efavirenz - Sustiva
-
Estramustine - Emcyt
-
Fluconazole - Diflucan
-
Indinavir - Crixivan
-
Itraconazole - Sporanox
-
Ketoconazole - Nizoral
-
Methadone - Dolophine
-
Methotrexate - Mexate
-
Mexiletine - Mexitil
-
Nelfinavir - Viracept
-
Nevirapine - Viramune
-
Oxtriphylline - Choledyl
-
Quinidine - Quinidex
-
Ritonavir - Norvir
-
Saquinavir - Fortovase, Invirase
-
Theophylline - Theo-Dur, Somophyllin-T
-
Tocainide - Tonocard
-
Verapamil - Calan Rifampin, isoniazid, pyrazinamide,
and ethambutol combination may decrease the side effects of medication
-
Disulfiram - Antabuse This drug may increase the
risk of liver damage and side effects, such as dizziness, lack of coordination,
irritability and inability to sleep
-
Estrogens - female hormones
-
Oral contraceptives - birth control pills containing estrogen
-
Phenytoin - Dilantin Rifampin, isoniazid, pyrazinamide,
and ethambutol combination may decrease the side effects of medication. If
you are taking oral contraceptives, this may increase the risk of pregnancy.
These medication may also increase the risk of liver damage if taken with
rifampin, isoniazid, pyrazinamide and ethambutol combination
Other Information for using
The presence of other medical
problems may effect the use of rifampin, isoniazid, pyrazinamide and ethambutol
combination. Make sure you tell your family doctor if you have any other medical
problems, especially:
-
Alcohol abuse - or history of
-
Liver disease There may be an increased risk of getting hepatitis
if you take this drug and drink alcohol daily
-
Convulsive disorders such as seizures or epilepsy This drug
may increase the frequency of convulsions - seizures in some diseaseds
-
Gout - history of This drug may worsen or cause a gout
attack in diseaseds with a history of gout
-
Kidney disease - severe There may be an increased risk of
side effects in diseaseds with severe kidney disease
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