Rifampin and Isoniazid - Systemic
Brand Names
Rifamate, rifampicin and isoniazid
Rifampin and Isoniazid *** Before Using *** How to Use *** Fore Safe Use *** Side Effects
Before Using
In deciding to using a medication,
the chance of taking the drug must be weighed against the good it will
do. This is a decision you will make. For rifampin and isoniazid
combination, the following must be considered
Allergic reaction
Tell your family doctor if you have any unusual or
allergy to ethionamide - Trecator-SC, pyrazinamide, niacin
- Nicobid, nicotinic acid, rifampin - Rifadin, rifabutin -
Mycobutin, or isoniazid - INH, Nydrazid. Also tell your health care
professional if you are allergic to any other substances, such as foods, preservatives,
or dyes.
Pregnancy care
Pregnant women with tuberculosis - TB must be treated
with TB medication, including isoniazid and rifampin. Rifampin and isoniazid
combination has not been shown to cause birth defects or other problems in
humans. However, rifampin rarely causing bleeding in newborn babies and mothers
when it was taken during the last weeks of pregnancy. Always studies in rats
and mice have shown that rifampin given in high doses causes birth defects,
usually backbone problems - spina bifida and cleft palate.
Breast-feeding problem
Rifampin and isoniazid both pass into the breast
milk. However, rifampin and isoniazid have not been reported to cause problems
in nursing babies.
Use for Children
Rifampin and isoniazid combination is not recommended
for use in child.
Elderly care
Liver problems are more likely to occur in diseaseds
over 50 years of age who are taking isoniazid-containing medication.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When you are taking
rifampin and isoniazid combination, it is especially important that your health
care professional know if you are taking any of the following:
-
Acetaminophen - Tylenol - with long-term, high-dose use
-
Alfentanil - Alfenta
-
Amiodarone - Cordarone
-
Anabolic steroids - nandrolone " Anabolin ", oxandrolone "
Anavar ", oxymetholone " Anadrol ", stanozolol " Winstrol "
-
Androgens - male hormones
-
Antithyroid agents - drug for overactive thyroid
-
Carbamazepine - Tegretol
-
Carmustine - BiCNU
-
Chloroquine - Aralen
-
Dantrolene - Dantrium
-
Daunorubicin - Cerubidine
-
Disulfiram - Antabuse
-
Divalproex - Depakote
-
Etretinate - Tegison
-
Gold salts - drug for arthritis
-
Hydroxychloroquine - Plaquenil
-
Mercaptopurine - Purinethol
-
Methyldopa - Aldomet
-
Naltrexone - Trexan - with long-term, high-dose use
-
Phenothiazines - acetophenazine " Tindal ", chlorpromazine "
Thorazine ", fluphenazine " Prolixin ", mesoridazine " Serentil ",
perphenazine " Trilafon ", prochlorperazine " Compazine ", promazine
" Sparine ", promethazine " Phenergan ", thioridazine " Mellaril ",
trifluoperazine " Stelazine ", triflupromazine " Vesprin ", trimeprazine
" Temaril "
-
Plicamycin - Mithracin
-
Valproic acid - Depakene These medication may increase
the risk of liver damage if taken with rifampin and isoniazid combination
-
Aminophylline - Somophyllin
-
Anticoagulants - blood thinners
-
Antidiabetics, oral - diabetes drug you take by mouth
-
Chloramphenicol
-
Corticosteroids - cortisone-like drug
-
Digitalis glycosides - heart drug
-
Disopyramide - Norpace
-
Estramustine - EMCYT
-
Fluconazole - Diflucan
-
Human immunodeficiency virus - HIV protease inhibitors - medication
for the treat of HIV infection
-
Itraconazole - Sporanox
-
Ketoconazole - Nizoral
-
Methadone - Dolophine
-
Methotrexate - Mexate
-
Mexiletine - Mexitil
-
Oxtriphylline - Choledyl
-
Quinidine - Quinidex
-
Theophylline - Theo-Dur, Somophyllin-T
-
Tocainide - Tonocard
-
Verapamil - Calan Rifampin and isoniazid combination
may decrease the side effects of medication
-
Disulfiram - Antabuse This drug may increase the
risk of liver damage and side effects, such as dizziness, lack of coordination,
irritability and inability to sleep
-
Estrogens - female hormones
-
Oral contraceptives - birth control pills containing estrogen
-
Phenytoin - Dilantin Rifampin and isoniazid combination
may decrease the side effects of medication. If you are taking oral contraceptives,
this may increase the risk of pregnancy. These medication may also increase
the risk of liver damage if taken with rifampin and isoniazid combination
Other Information for using
The presence of other medical
problems may effect the use of rifampin and isoniazid combination. Make sure
you tell your family doctor if you have any other medical problems, especially:
-
Alcohol abuse - or history of
-
Liver disease There may be an increased risk of getting hepatitis
if you take this drug and drink alcohol daily
-
Convulsive disorders such as seizures or epilepsy Rifampin
and isoniazid combination may increase the frequency of seizures - convulsions
in some diseaseds
-
Kidney disease - severe There may be an increased risk of
side effects in diseaseds with severe kidney disease
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