Rauwolfia Alkaloids and Thiazide Diuretics - Systemic
Rauwolfia Alkaloids and Thiazide Diuretics *** Before Using *** How to Use *** Fore Safe Use *** Side Effects
Before Using
In deciding to using a medication,
the chance of taking the drug must be weighed against the good it will
do. This is a decision you will make. For rauwolfia alkaloids
and thiazide diuretics, the following must be considered
Allergic reaction
Tell your family doctor if you have any unusual or
allergy to sulfonamides - sulfa drugs, thiazide diuretics - water
pills, or rauwolfia alkaloids. Also tell your health care professional if
you are allergic to any other substance, such as foods, preservatives, or
dyes.
Pregnancy care
Too much use of thiazide diuretics - contained in
this combination drug during pregnancy may cause unwanted effects including
jaundice, blood problems and low potassium in the baby. Too much use of rauwolfia
alkaloids may cause difficult breathing, low temperature and loss of appetite
in the baby. This drug has not been shown to cause birth defects.
In rats, use of rauwolfia alkaloids during pregnancy decreases newborn survival
rates. Be sure that you have discussed this with your family doctor before taking
this drug.
Breast-feeding problem
Rauwolfia alkaloids pass into breast milk and may
cause unwanted effects - difficult breathing, low temperature, loss of appetite
in infants of mothers taking it in large doses. Thiazide diuretics also pass
into breast milk. Be sure you have discussed this with your family doctor before
taking this drug.
Use for Children
Although there is no special info comparing
use of these medication in child with use in other age groups, these medication
are not expected to cause various side effects or problems in child than
they do in adults.
Elderly care
Many medication have not been studied specifically
in elderly people. Therefore, it may not be known whether they work exactly
the same way they do in adults people. Although there is no special info
comparing use of rauwolfia alkaloid and thiazide diuretic combinations in
the elderly with use in other age groups, this drug is not expected to
cause various side effects or problems in elderly people than it does in younger
adults. However, drowsiness, dizziness, or faintness or symptoms of too much
potassium loss may be more likely to occur in the elderly, who are more sensitive
to the effects of rauwolfia alkaloids and thiazide diuretics.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When you are taking
rauwolfia alkaloids and thiazide diuretics, it is especially important that
your health care professional know if you are taking any of the following:
-
Cholestyramine
-
Colestipol Use with thiazide diuretics may prevent the diuretic
from help you; take the diuretic at least 1 hour before or 4 hours
after cholestyramine or colestipol
-
Digitalis glycosides - heart drug Thiazide diuretics may
cause low potassium in the blood, which can lead to symptoms of digitalis
toxicity
-
Lithium - Lithane chance of lithium overdose, even at usual
doses, may be increased
-
Monoamine oxidase - MAO inhibitor activity - isocarboxazid
" Marplan ", phenelzine " Nardil ", procarbazine " Matulane ",
selegiline " Eldepryl ", tranylcypromine " Parnate " Taking
a rauwolfia alkaloid while you are taking or within 2 weeks of taking MAO
inhibitors may increase the risk of central nervous system depression or may
cause a severe high blood pressure reaction
Other Information for using
The presence of other medical
problems may effect the use of rauwolfia alkaloids and thiazide diuretics.
Make sure you tell your family doctor if you have any other medical problems, especially:
-
Allergies or other breathing problems such as asthma Rauwolfia
alkaloids can cause breathing problems
-
Diabetes mellitus - sugar diabetes Thiazide diuretics may change
the amount of diabetes drug needed
-
Gallstones
-
Stomach ulcer
-
Ulcerative colitis Rauwolfia alkaloids increase activity of
the stomach, which may make the condition worse
-
Gout - history of Thiazide diuretics may increase the amount
of uric acid in the blood, which can lead to gout
-
Heart disease Rauwolfia alkaloids can cause heart rhythm problems
or slow heartbeat
-
Kidney disease Some diseaseds may not do well when blood pressure
is lowered by this drug. If kidney disease is severe, thiazide diuretics
may not work
-
Liver disease If thiazide diuretics cause loss of too much
water from the body, liver disease can become much worse
-
Lupus erythematosus - history of Thiazide diuretics may worsen
the condition
-
Mental depression - or history of Rauwolfia alkaloids cause
mental depression
-
Pancreatitis - inflammation of pancreas
-
Parkinson's disease Rauwolfia alkaloids can cause parkinsonism-like
effects
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