Procarbazine - Systemic
Brand Names
Matulane, Natulan
Procarbazine *** Before Using *** How to Use *** Fore Safe Use *** Side Effects
Before Using
In deciding to using a medication,
the chance of taking the drug must be weighed against the good it will
do. This is a decision you will make. For procarbazine, the
following must be considered
Allergic reaction
Tell your family doctor if you have any unusual or
allergy to procarbazine.
Pregnancy care
Tell your family doctor if you are pregnant or if you intend
to have children. This drug may cause birth defects or premature birth
if either the male or female is taking it at the time of conception or if
it is taken during pregnancy. Procarbazine causes birth defects frequently
in pets. In addition, many cancer medication may cause sterility which could
be permanent. Although sterility has not been reported with this drug,
procarbazine does effect production of sperm and the possibility must be
kept in mind.Be sure that you have discussed this with your family doctor before taking this
drug. It is best to use some kind of birth control while you are taking
procarbazine. Tell your family doctor right away if you think you have become pregnant
while taking procarbazine.
Breast-feeding problem
Tell your family doctor if you are breast-feeding or if
you intend to breast-feed during treat with this drug. Because procarbazine
may cause serious side effects, breast-feeding is generally not recommended
while you are taking it.
Use for Children
Although there is no special info about the
use of procarbazine in child, it is not expected to cause various side
effects or problems in child than it does in adults.
Elderly care
Side effects may be more likely to occur in elderly
diseaseds, who are usually more sensitive to the effects of procarbazine.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When you are taking
procarbazine, it is especially important that your health care professional
know if you are taking any of the following:
-
Amantadine - Symmetrel
-
Anticholinergics - drug to help reduce stomach acid and for abdominal
or stomach spasms or cramps
-
Antidiabetics, oral - diabetes drug you take by mouth
-
Antidyskinetics - drug for Parkinson's disease or other conditions
effecting control of muscles
-
Antihistamines
-
Antipsychotics - drug for mental illness
-
Buclizine - Bucladin
-
Central nervous system - CNS depressants
-
Cyclizine - Marezine
-
Disopyramide - Norpace
-
Flavoxate - Urispas
-
Insulin
-
Ipratropium - Atrovent
-
Meclizine - Antivert
-
Orphenadrine - Norflex
-
Oxybutynin - Ditropan
-
Procainamide - Pronestyl
-
Promethazine - Phenergan
-
Quinidine - Quinidex
-
Trimeprazine - Temaril Effects of these medication may
be increased by procarbazine
-
Amphetamines
-
Appetite suppressants - diet pills
-
Dextromethorphan - Delsym
-
Levodopa - Dopar
-
Medicine for asthma or other breathing problems
-
Medicine for colds, sinus problems, or hay fever or other allergies
- including nose drops or sprays
-
Methyldopa - Aldomet
-
Methylphenidate - Ritalin
-
Narcotic pain drug Taking any of these medication while
you are taking or within 2 weeks of taking procarbazine may cause a severe
high blood pressure reaction
-
Amphotericin B by injection - Fungizone
-
Antithyroid agents - drug for overactive thyroid
-
Azathioprine - Imuran
-
Chloramphenicol - Chloromycetin
-
Colchicine
-
Flucytosine - Ancobon
-
Interferon - Intron A, Roferon-A
-
Plicamycin - Mithracin
-
Zidovudine - Retrovir
-
If you have ever been treated with x-rays or cancer medication Procarbazine
may increase the side effects of medication or radiation therapy on the blood
-
Buspirone - BuSpar chance of increased blood pressure
-
Carbamazepine - Tegretol
-
Cyclobenzaprine - Flexeril
-
Maprotiline - Ludiomil
-
Monoamine oxidase - MAO inhibitor activity - isocarboxazid "
Marplan ", phenelzine " Nardil ", selegiline " Eldepryl ", tranylcypromine
" Parnate "
-
Tricyclic antidepressants - amitriptyline " Elavil ", amoxapine
" Asendin ", clomipramine " Anafranil ", desipramine " Pertofrane ",
doxepin " Sinequan ", imipramine " Tofranil ", nortriptyline "
Aventyl ", protriptyline " Vivactil ", trimipramine " Surmontil " Taking
procarbazine while you are taking or within 2 weeks of taking any of these
medication may cause a severe high blood pressure reaction
-
Cocaine Use of cocaine while you are taking or within 2 weeks
of taking procarbazine may cause a severe high blood pressure reaction
-
Fluoxetine - Prozac Taking this drug while you are
taking or within 2 weeks of taking procarbazine may cause a severe high blood
pressure reaction or may lead to confusion, agitation, restlessness and stomach
problems
-
Guanadrel - Hylorel
-
Guanethidine - Ismelin
-
Rauwolfia alkaloids - alseroxylon " Rauwiloid ", deserpidine "
Harmonyl ", rauwolfia serpentina " Raudixin ", reserpine " Serpasil " Taking
these medication while you are taking or within 1 week of taking procarbazine
may cause a severe high blood pressure reaction
Other Information for using
The presence of other medical
problems may effect the use of procarbazine. Make sure you tell your family doctor
if you have any other medical problems, especially:
-
Angina - chest pain
-
Heart or blood vessel disease
-
Heart attack or stroke - recent Lowered blood pressure causing
by procarbazine may make problems associated with some of these conditions
worse
-
Chickenpox - including recent exposure
-
Herpes zoster - shingles chance of severe disease effecting other
parts of the body
-
Diabetes mellitus - sugar diabetes Procarbazine may change
the amount of diabetes drug needed
-
Epilepsy Procarbazine may change the seizures
-
Headaches - severe or frequent You may not realize when a severe
headache is causing by a dangerous reaction to procarbazine
-
Infection Procarbazine can reduce immunity to infection
-
Kidney disease Effects may be increased because of slower removal
of procarbazine from the body
-
Liver disease Procarbazine can cause severe liver disease to
become much worse
-
Mental illness - or history of Some cases of mental illness
may be worsened
-
Overactive thyroid Increased risk of dangerous reaction to
procarbazine
-
Parkinson's disease May be worsened
-
Pheochromocytoma Blood pressure may be effected
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