Probenecid and Colchicine : Before Using - ColBenemid, Col-Probenecid, Proben-C

Probenecid and Colchicine - Systemic

Brand Names

ColBenemid, Col-Probenecid, Proben-C Probenecid and Colchicine *** Before Using *** How to Use *** Fore Safe Use *** Side Effects

Before Using

In deciding to using a medication, the chance of taking the drug must be weighed against the good it will do. This is a decision you will make. For probenecid and colchicine combination, the following must be considered

Allergic reaction

Tell your family doctor if you have any unusual or allergy to probenecid or to colchicine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy care

Probenecid has not been shown to cause birth defects or other problems. Although studies with colchicine have not been done in pregnant women, some reports have suggested that use of colchicine during pregnancy can cause harm to the fetus. Always studies in pets have shown that colchicine causes birth defects. Therefore, do not begin taking this drug during pregnancy and do not become pregnant while taking it, unless you have first discussed this problem with your family doctor. Always check with your family doctor immediately if you suspect that you have become pregnant while taking this drug.

Breast-feeding problem

This drug has not been reported to cause problems in nursing babies.

Use for Children

Studies on this combination drug have been done only in adult diseaseds and there is no special info about its use in child.

Elderly care

Elderly people are especially sensitive to the effects of colchicine. This may increase the risk of side effects during treat.

There is no special info comparing use of probenecid in the elderly with use in other age groups.

Drug interactions

Although certain medication must not be using together at all, in other cases two various medication may be using together even if an interaction might occur. In these cases, your family doctor may want to change the dose, or other precautions may be necessary. When you are taking probenecid and colchicine combination, it is especially important that your health care professional know if you are taking any of the following:

Amphotericin B by injection - Fungizone
Antineoplastics - cancer drug
Antithyroid agents - drug for overactive thyroid
Azathioprine - Imuran
Cyclophosphamide - Cytoxan
Flucytosine - Ancobon
Ganciclovir - Cytovene
Interferon - Intron A, Roferon-A
Mercaptopurine - Purinethol
Methotrexate - Mexate
Phenylbutazone - Butazolidin
Plicamycin - Mithracin
Zidovudine - AZT, Retrovir Taking any of these medication together with colchicine may increase the risk of serious side effects. Always the risk of serious side effects may be increased when antineoplastics - cancer drug, methotrexate, phenylbutazone, or zidovudine are taken together with probenecid

Aspirin or other salicylates, including bismuth subsalicylate - Pepto-Bismol These medication may keep probenecid from help you for treating gout, depending on the amount of aspirin or other salicylate that you take and how often you take it

Heparin Probenecid may increase the effects of heparin, which increases the risk of side effects

Indomethacin - Indocin
Ketoprofen - Orudis Probenecid may increase the blood levels of these medication, which increases the risk of side effects

Medicine for infection, including tuberculosis or virus infection Probenecid may increase the blood levels of many of these medication, which may increase the risk of side effects. Always the risk of serious side effects may be increased when some of these medication are taken together with colchicine

Nitrofurantoin - Furadantin Probenecid may keep nitrofurantoin from help you

Other Information for using

The presence of other medical problems may effect the use of probenecid and colchicine combination. Make sure you tell your family doctor if you have any other medical problems, especially:

Alcohol abuse
Blood disease
Cancer being treated by antineoplastics - cancer drug or radiation - x-rays
Heart disease - severe
Intestinal disease - severe
Kidney disease or stones - or history of
Liver disease
Stomach ulcer or other stomach problems - or history of The risk of serious side effects may be increased