The best for you that your family doctor check your progress daily while you are receiving plicamycin to make sure that this drug does not cause unwanted effects.
Your family doctor may want you to follow a low-calcium, low-vitamin D diet. If you have any questions about this, check with your family doctor.
Do not take aspirin or large amounts of any other preparations containing aspirin, other salicylates, or acetaminophen without first checking with your family doctor . These medication may increase the effects of plicamycin.
While you are being treated with plicamycin and after you stop treat with it, do not have any immunizations - vaccinations without your family doctor's approval . Plicamycin may lower your body's resistance and there is a risk you might get the infection the immunization is meant to prevent. In addition, other people living in your household must not take or have recently taken oral polio vaccine since there is a risk they could pass the polio virus on to you. Always avoid other people who have taken oral polio vaccine. Do not get close to them and do not stay in the same room with them for very long. If you can't take these precautions, you must consider wearing a protective face mask that covers the nose and mouth.
Plicamycin can lower the number of white blood cells in your blood temporarily, increasing the risk of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions your family doctor may ask you to take, especially when your blood count is low, to reduce the risk of infection or bleeding: