Your family doctor must check your progress at regular appointments to allow dose adjustments and help reduce side effects.
Do not stop taking this drug without first checking with your family doctor . Your family doctor may want you to reduce gradually the amount you are taking before stopping completely. This is to prevent side effects and to prevent your condition from becoming worse.
Do not take this drug within two hours of taking antacids or drug for diarrhea. Taking these products too close together may make this drug less effective.
This drug will add to the effects of alcohol and other CNS depressants - medication that cause drowsiness. Some examples of CNS depressants are antihistamines or drug for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping drug; prescription pain drug or narcotics; barbiturates; drug for seizures; or anesthetics, including some dental anesthetics. Check with your family doctor before taking any of the above while you are using this drug .
Before having any kind of surgery, dental treat, or emergency treat, tell the family doctor or dentist in charge that you are taking this drug . Taking perphenazine and amitriptyline combination together with medication that are using during surgery or dental or emergency treats may increase the CNS depressant effects.
This drug may cause some people to become drowsy or less alert than they are normally, especially during the first few weeks of treat. Even if this drug is taken only at bedtime, it may cause some people to feel drowsy or less alert on arising Make sure you know how you react to this drug before you drive, use machines, or do anything else that could be dangerous if you are not alert .
Dizziness, lightheadedness, or fainting may occur , especially when you get up from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your family doctor.
This drug may make you sweat less, causing your body temperature to increase Use extra care not to become overheated during exercise or hot weather while you are taking this drug , since overheating may result in heat stroke. Always hot baths or saunas may make you feel dizzy or faint.
Perphenazine and amitriptyline combination may cause dryness of the mouth. For temporary relief, use sugarless gum or candy, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your family doctor or dentist. Continuing dryness of the mouth may increase the risk of dental disease, including tooth decay, gum disease and fungus infections.
Perphenazine may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking this drug:
If you have a severe reaction from the sun, check with your family doctor .