How to Use

Amoxicillin and clavulanate combination may be taken on a full or empty stomach. Taking amoxicillin and clavulanate combination with food may decrease the risk of diarrhea, nausea and vomiting.

For diseaseds taking the oral liquid form of amoxicillin and clavulanate combination :

• Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.
• Do not use after the expiration date on the label. The drug may not work properly after that date. If you have any questions about this, check with your pharmacist.

For diseaseds taking the chewable tablet form of amoxicillin and clavulanate combination :

• Tablets must be chewed or crushed before they are swallowed.

To help clear up your infection completely, keep taking this drug for the full time of treat , even if you begin to feel better after a few days.

This drug works best when there is a constant amount in the blood or urine To help keep the amount constant, do not miss any doses. Always it is best to take the doses at evenly spaced times, day and night . For example, if you are to take four doses a day, the doses must be spaced about 6 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your drug, check with your health care professional.

Dosage

The number of tablets or teaspoonfuls of suspension that you take depends on the strength of the drug. Always the number of doses you take each day, the time allowed between doses and the length of time you take the drug depend on the medical problem for which you are taking a penicillin and beta-lactamase inhibitor combination .

For amoxicillin and clavulanate combination
• For bacterial infections:
  • For oral dosage forms - chewable tablets and suspension:
    • Adults, teenagers and children weighing more than 40 kilograms - kg - 88 pounds 250 to 500 milligrams - mg of amoxicillin, in combination with 125 mg of clavulanate, every eight hours or 500 to 875 mg of amoxicillin, in combination with 125 mg of clavulanate, every twelve hours.
    • Neonates and infants up to 12 weeks - 3 months of age Dose is based on body weight and must be determined by your family doctor. The usual dose is 15 mg of amoxicillin per kg - 6.8 mg per pound of body weight every twelve hours.
    • Infants 3 months of age and older and children weighing up to 40 kg - 88 pounds 6.7 to 22.5 mg of amoxicillin per kg - 3 to 10.2 mg per pound of body weight, in combination with 1.7 to 3.2 mg of clavulanate per kg - 0.8 to 1.5 mg per pound of body weight, every eight or twelve hours.
  • For oral dosage form - tablets:
    • Adults, teenagers and children weighing more than 40 kg - 88 pounds 250 to 500 mg of amoxicillin, in combination with 125 mg of clavulanate, every eight hours or 500 to 875 mg of amoxicillin, in combination with 125 mg of clavulanate, every twelve hours.
    • Infants and children weighing up to 40 kg - 88 pounds The amoxicillin and clavulanate combination tablets are too strong for children weighing less than 40 kg - 88 pounds. The chewable tablets or oral suspension are using in these children.

For ampicillin and sulbactam combination
• For bacterial infections:
  • For injection dosage form:
    • Adults and teenagers 1 to 2 grams of ampicillin, in combination with 500 milligrams - mg to 1 gram of sulbactam, injected into a vein or a muscle every six hours.
    • Children 1 to 12 years of age Dose must be determined by your family doctor.
    • Children up to 1 year of age Use and dose must be determined by your family doctor.

For piperacillin and tazobactam combination
• For bacterial infections:
  • For injection dosage form:
    • Adults and teenagers 3 to 4 grams of piperacillin, in combination with 0.375 to 0.5 grams of tazobactam, injected into a vein every six to eight hours for seven to ten days.
    • Children up to 12 years of age Dose must be determined by your family doctor.

For ticarcillin and clavulanate combination
• For bacterial infections:
  • For injection dosage form:
    • Adults and teenagers weighing 60 kilograms - kg - 132 pounds or more 3 grams of ticarcillin, in combination with 100 milligrams - mg of clavulanate, injected into a vein every four to six hours.
    • Adults and teenagers weighing less than 60 kg - 132 pounds 50 mg of ticarcillin per kg - 22.7 mg per pound of body weight, in combination with 1.7 mg of clavulanate per kg - 0.8 mg per pound of body weight, injected into a vein every four to six hours.
    • Infants and children 1 month to 12 years of age 50 mg of ticarcillin per kg - 22.7 mg per pound of body weight, in combination with 1.7 mg of clavulanate per kg - 0.8 mg per pound of body weight, injected into a vein every four to six hours.
    • Infants up to 1 month of age Use and dose must be determined by your family doctor.

Missed dose If you miss a dose of this drug, take it as soon as possible. This will help to keep a constant amount of drug in the blood or urine. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage To store this drug:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store tablets in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the drug to break down.
• Store the oral liquid form of penicillins in the refrigerator because heat will cause this drug to break down. However, keep the drug from freezing. Follow the directions on the label.
• Do not keep outdated drug or drug no longer needed. Be sure that any discarded drug is out of the reach of children.