The best for you that your family doctor check your progress at regular appointments to make sure that this drug is help you and to check for unwanted effects.
Avoid alcoholic beverages until you have discussed their use with your family doctor . Alcohol may increase the harmful effects of this drug.
While you are being treated with mercaptopurine and after you stop treat with it, do not have any immunizations - vaccinations without your family doctor's approval . Mercaptopurine may lower your body's resistance and there is a risk you might get the infection the immunization is meant to prevent. In addition, other people living in your household must not take oral polio vaccine since there is a risk they could pass the polio virus on to you. Always avoid people who have taken oral polio vaccine. Do not get close to them and do not stay in the same room with them for very long. If you can't take these precautions, you must consider wearing a protective face mask that covers the nose and mouth.
Mercaptopurine can temporarily lower the number of white blood cells in your blood, increasing the risk of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:
Tell the family doctor in charge that you are taking this drug before you have any medical tests. The results of tests for the amount of sugar or uric acid in the blood measured by a machine called a sequential multiple analyzer - SMA may be effected by this drug.