Histamine H 2-receptor Antagonists - Systemic
Histamine H 2-receptor Antagonists *** Before Using *** How to Use *** Fore Safe Use *** Side Effects *** Additional Information
Before Using
In deciding to using a medication,
the chance of taking the drug must be weighed against the good it will
do. This is a decision you will make. For H 2
-blockers, the following must be considered
Allergic reaction
Tell your family doctor if you have any unusual or
allergy to cimetidine, famotidine, nizatidine, or ranitidine.
Pregnancy care
H 2
-blockers have not
been studied in pregnant women. In animal studies, famotidine and ranitidine
have not been shown to cause birth defects or other problems. However, one
study in rats suggested that cimetidine may effect male sexual development.
More studies are needed to confirm this. Always studies in rabbits with very
high doses have shown that nizatidine causes miscarriages and low birth weights.
Make sure your family doctor knows if you are pregnant or if you may become pregnant
before taking H 2
-blockers.
Breast-feeding problem
Cimetidine, famotidine, nizatidine and ranitidine
pass into the breast milk and may cause unwanted effects, such as decreased
amount of stomach acid and increased excitement, in the nursing baby. It may
be necessary for you to take another drug or to stop breast-feeding during
treat. Be sure you have discussed the chance and benefits of the drug
with your family doctor.
Use for Children
This drug has been tested in child and, in
effective doses, has not been shown to cause various side effects or problems
than it does in adults when using for short periods of time.
Elderly care
Confusion and dizziness may be especially likely
to occur in elderly diseaseds, who are usually more sensitive than younger
adults to the effects of H 2
-blockers.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When you are taking
or receiving H 2
-blockers it is especially important
that your health care professional know if you are taking any of the following:
-
Aminophylline - Somophyllin
-
Anticoagulants - blood thinners
-
Caffeine - NoDoz
-
Metoprolol - Lopressor
-
Oxtriphylline - Choledyl
-
Phenytoin - Dilantin
-
Propranolol - Inderal
-
Theophylline - Somophyllin-T
-
Tricyclic antidepressants - amitriptyline " Elavil ", amoxapine
" Asendin ", clomipramine " Anafranil ", desipramine " Pertofrane ",
doxepin " Sinequan ", imipramine " Tofranil ", nortriptyline "
Aventyl ", protriptyline " Vivactil ", trimipramine " Surmontil " Use
of these medication with cimetidine has been shown to increase the effects
of cimetidine. This is less of a problem with ranitidine and has not been
reported for famotidine or nizatidine. However, all of the H 2
-blockers are similar, so drug interactions may occur with any of
them
-
Itraconazole - Sporanox
-
Ketoconazole - Nizoral H 2
-blockers
may decrease the effects of itraconazole or ketoconazole; H 2
-blockers must be taken at least 2 hours after these medication
Other Information for using
The presence of other medical
problems may effect the use of H 2
-blockers.
Make sure you tell your family doctor if you have any other medical problems, especially:
-
Kidney disease
-
Liver disease The H 2
-blocker
may build up in the bloodstream, which may increase the risk of side effects
-
Phenylketonuria - PKU Some H 2
-blockers
contain aspartame. Aspartame is converted to phenylalanine in the body and
must be using with caution in diseaseds with PKU. The Pepcid AC brand of famotidine
chewable tablets contains 1.4 mg of phenylalanine per 10-mg dose. The Pepcid
RPD brand of famotidine oral dispersible tablets contains 1.05 mg of phenylalanine
per 20-mg dose. The Zantac brand of ranitidine EFFERdose tablets and EFFERdose
granules contain 16.84 mg of phenylalanine per 150-mg dose
-
Weakened immune system - difficulty fighting infection Decrease
in stomach acid causing by H 2
-blockers may increase
the possibility of a certain type of infection
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