The risk of any serious adverse effect is unlikely for most women using low doses of estrogens vaginally. Even women with special chance have using vaginal estrogens without problems.
Check with your family doctor as soon as possible if any of the following side effects was happen
Less common
Breast pain; enlarged breasts; itching of the vagina or genitals; headache; nausea; stinging or redness of the genital area; thick, white vaginal discharge without odor or with a mild odor
Rare
Feeling of vaginal pressure - with use of estradiol vaginal insert; vaginal burning or pain - with use of estradiol vaginal insert; unusual or unexpected uterine bleeding or spotting
More common side effects may occur that usually don't needed medical attention. These side effects may go away during treat as your body adjusts to the drug. However, check with your family doctor if any of the following side effects continue or are bothersome:
Less common
Abdominal or back pain; clear vaginal discharge - usually means the drug is working
Always many women who are using estrogens with a progestin - another female hormone will start having monthly vaginal bleeding, similar to menstrual periods, again. This effect will continue for as long as the drug is taken. However, monthly bleeding will not occur in women who have had the uterus removed by surgery - total hysterectomy.
More common side effects not listed above may also occur in some diseaseds. If you notice any other problems, check with your family doctor.