Epirubicin - Systemic
Brand Names
Ellence, Pharmorubicin PFS
Epirubicin *** Before Using *** How to Use *** Fore Safe Use *** Side Effects *** Additional Information
Before Using
In deciding to using a medication,
the chance of taking the drug must be weighed against the good it will
do. This is a decision you will make. For epirubicin, the
following must be considered
Allergic reaction
Tell your family doctor if you have any unusual
or allergy to daunorubicin, doxorubicin, epirubicin, idarubicin,
or mitoxantrone.
Pregnancy care
There is a risk that this drug may cause
birth defects if either the male or female is receiving it at the time of
conception or if it is taken by the mother during pregnancy. Studies in rats
and rabbits have shown that epirubicin causes birth defects in the fetus and
other problems - including miscarriage. In addition, many cancer medication
may cause sterility, which could be permanent. Although sterility has been
reported in pets and humans with this drug, this is less likely to
occur than in pets.Be sure that you have discussed these possible effects with your family doctor
before receiving this drug. Before receiving epirubicin make sure your
family doctor knows if you are pregnant or if you may become pregnant. It is best
to use some kind of birth control while you are receiving epirubicin. Tell
your family doctor right away if you think you have become pregnant while receiving
epirubicin.
Breast-feeding problem
It is not known whether epirubicin passes into
breast milk. However, epirubicin is not recommended during breast-feeding,
because it may cause unwanted effects in nursing babies.
Use for Children
Studies on this drug have been done only in
adult diseaseds and there is no special info comparing use of epirubicin
in child with use in other age groups. Heart problems are more likely to
occur in child younger than 2 years of age.
Elderly care
Heart problems are more likely to occur in the
elderly, who may have existing heart disease. The elderly may also be more
likely to have blood problems. Always elderly diseaseds may not be able to metabolize
the medication as quickly as younger diseaseds, which may put them at risk
for added toxicity.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When receiving epirubicin
it is especially important that your health care professional know if you
are taking any of the following:
-
Acetaminophen - Tylenol - with long-term, high-dose use
-
Amiodarone - Cordarone
-
Anabolic steroids, nandrolone " Anabolin ", oxandrolone "
Anawar ", oxymetholone " Anadrol ", stanozolol " Winstrol "
-
Androgens - male hormones or
-
Carmustine - BiCNU
-
Chloroquine - Aralen
-
Dantrolene - Dantrium
-
Disulfiram - Antabuse
-
Divalproex - Depakote
-
Estrogens - female hormones
-
Etretinate - Tegison
-
Hydroxychloroquine - Plaquenil
-
Methyldopa - Aldomet
-
Naltrexone - Trexan - with long-term, high-dose use
-
Oral contraceptives - birth control pills containing estrogen
-
Phenothiazines - acetophenazine " Tindal ", chlorpromazine "
Thorazine ", fluphenazine " Prolixin ", mesoridazine " Serentil ",
perphenazine " Trilafon ", prochlorperazine " Compazine ", promazine
" Sparine ", promethazine " Phenergan ", thioridazine " Mellaril ",
trifluoperazine " Stelazine ", triflupromazine " Vesprin ", trimeprazine
" Temaril "
-
Phenytoin - Dilantin
-
Valproic acid - Depakene Concurrent use of these agents
with epirubicin may increase risk of liver problems
-
Acyclovir - Zovirax
-
Anticonvulsants - seizure drug
-
Antidiabetics, oral - diabetes drug taken by mouth
-
Antipsychotics - drug for mental illness
-
Captopril - Capoten
-
Enalapril - Vasotec
-
Flecainide - Tambocor
-
Imipenem
-
Inflammation or pain drug, except narcotics
-
Lisinopril - Prinivil, Zestril
-
Maprotiline - Ludiomil
-
Penicillamine - Cuprimine
-
Pimozide - Orap
-
Procainamide - Pronestyl
-
Promethazine - Phenergan
-
Ramipril - Altace
-
Sulfasalazine - Azulfidine
-
Tiopronin - Thiola
-
Tocainide - Tonocard
-
Tricyclic antidepressants - drug for depression
-
Trimeprazine - Temaril Concurrent use of these agents
with epirubicin may cause blood disorders
-
Amphotericin B, injection - Fungizone
-
Antineoplastics, other - cancer drug
-
Azathioprine - Imuran
-
Chloramphenicol - Chloromycetin
-
Colchicine
-
Cyclophosphamide - e.g. Cytoxan
-
Flucytosine - e.g. Ancoban
-
Ganciclovir - Cytovene
-
Interferon - Intron A, Roferon-A
-
Zidovudine - AZT, Retrovir Concurrent use of these agents
with epirubicin increases the risk of infection
-
Anti-infectives, by mouth or injection - drug for infection
-
Carbamazepine - Tegretol
-
Gold salts - drug for arthritis Concurrent use with epirubicin
may cause blood disorders and increase risk of liver problems
-
Antithyroid agents - drug for overactive thyroid
-
Mercaptopurine - Purinethol
-
Methotrexate - Rheumatrex
-
Plicamycin - Mithracin Concurrent use with epirubicin
increases the risk of infection and may increase the risk of liver problems
-
Bepridil - Vascor
-
Diltiazem - Cardizem
-
Flunarizine - Sibelium
-
Isradipine - DynaCirc
-
Nicardipine - Cardene
-
Nifedipine - Procardia
-
Nimodipine - Nimotop
-
Verapamil - Calan
-
other heart medication Concurrent use of these agents with epirubicin
may contribute to heart damage and failure
-
Cimetidine - Tagamet Cimetidine increases the amount
of time epirubicin stays in the body.
-
Daunorubicin - Cerubidine or
-
Doxorubicin - Adriamycin
-
Idarubicin - Idamycin
-
Mitoxantrone - Novantrone Concurrent use of maximum cumulative
doses of other anthracyclines with epirubicin may increase risk of heart damage,
secondary leukemia and stomach and blood problems. Concurrent use may increase
risk of liver problems.
-
If you have ever been treated with radiation or cancer medication Epirubicin
may increase the side effects of medication or radiation therapy on the blood
-
If you have ever been treated with radiation to your chest chance
of heart problems causing by epirubicin may be increased
Other Information for using
The presence of other medical
problems may effect the use of epirubicin. Make sure you tell your family doctor
if you have any other medical problems, especially:
-
Bone marrow depression
-
Viral, fungal, or bacterial infection There may be an increased
risk of infections or worsening infections because of the body's reduced ability
to fight them
-
Heart disease chance of heart problems causing by epirubicin may
be increased
-
Liver disease Effects of epirubicin may be increased because
of its slower removal from the body
-
Tumor cell infiltration of bone marrow Increased susceptibility
for cancer to spread to bone marrow
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