Side Effects

In rats, spironolactone has been found to increase the risk of tumors. It is not known if spironolactone increases the risk of tumors.

Check with your family doctor as soon as possible if any of the following side effects was happen

Rare

For amiloride, spironolactone and triamterene

Skin rash or itching; shortness of breath

For spironolactone and triamterene only - in addition to effects listed above

Cough or hoarseness; fever or chills; lower back or side pain; painful or difficult urination

For triamterene only - in addition to effects listed above

Black, tarry stools; blood in urine or stools; bright red tongue; burning, inflamed feeling in tongue; cracked corners of mouth; lower back pain - severe; pinpoint red spots on skin; unusual bleeding or bruising; weakness

Signs and symptoms of too much potassium

Confusion; irregular heartbeat; nervousness; numbness or tingling in hands, feet, or lips; shortness of breath or difficult breathing; unusual tiredness or weakness; weakness or heaviness of legs

Other side effects may occur that usually don't needed medical attention. These side effects may go away during treat as your body adjusts to the drug. However, check with your family doctor if any of the following side effects continue or are bothersome:

More common - less common with amiloride and triamterene

Nausea and vomiting; stomach cramps and diarrhea

Less common

For amiloride, spironolactone and triamterene

Dizziness; headache

For amiloride and spironolactone only - in addition to effects listed above

Decreased sexual ability

For amiloride only - in addition to effects listed above

Constipation; muscle cramps

For spironolactone only - in addition to effects listed above for spironolactone

Breast tenderness in females; clumsiness; deepening of voice in females; enlargement of breasts in males; inability to have or keep an erection; increased hair growth in females; irregular menstrual periods; sweating

For triamterene only - in addition to effects listed above for triamterene

Increased sensitivity of skin to sunlight

Signs and symptoms of too little sodium

Drowsiness; dryness of mouth; increased thirst; lack of energy

For male diseaseds :

• Spironolactone sometimes causes enlarged breasts in males, especially when they take large doses of it for a long time. Breasts usually decrease in size gradually over few months after this drug is stopped. If you have any questions about this, check with your family doctor.

More common side effects not listed above may also occur in some diseaseds. If you notice any other problems, check with your family doctor.