In rats, spironolactone has been found to increase the risk of tumors. It is not known if spironolactone increases the risk of tumors.
Check with your family doctor as soon as possible if any of the following side effects was happen
Rare
For amiloride, spironolactone and triamterene
Skin rash or itching; shortness of breath
For spironolactone and triamterene only - in addition to effects listed above
Cough or hoarseness; fever or chills; lower back or side pain; painful or difficult urination
For triamterene only - in addition to effects listed above
Black, tarry stools; blood in urine or stools; bright red tongue; burning, inflamed feeling in tongue; cracked corners of mouth; lower back pain - severe; pinpoint red spots on skin; unusual bleeding or bruising; weakness
Signs and symptoms of too much potassium
Confusion; irregular heartbeat; nervousness; numbness or tingling in hands, feet, or lips; shortness of breath or difficult breathing; unusual tiredness or weakness; weakness or heaviness of legs
Other side effects may occur that usually don't needed medical attention. These side effects may go away during treat as your body adjusts to the drug. However, check with your family doctor if any of the following side effects continue or are bothersome:
More common - less common with amiloride and triamterene
Nausea and vomiting; stomach cramps and diarrhea
Less common
For amiloride, spironolactone and triamterene
Dizziness; headache
For amiloride and spironolactone only - in addition to effects listed above
Decreased sexual ability
For amiloride only - in addition to effects listed above
Constipation; muscle cramps
For spironolactone only - in addition to effects listed above for spironolactone
Breast tenderness in females; clumsiness; deepening of voice in females; enlargement of breasts in males; inability to have or keep an erection; increased hair growth in females; irregular menstrual periods; sweating
For triamterene only - in addition to effects listed above for triamterene
Increased sensitivity of skin to sunlight
Signs and symptoms of too little sodium
Drowsiness; dryness of mouth; increased thirst; lack of energy
For male diseaseds :
More common side effects not listed above may also occur in some diseaseds. If you notice any other problems, check with your family doctor.