Difenoxin and Atropine : Before Using

Difenoxin and Atropine - Systemic

Brand Names

Motofen Difenoxin and Atropine *** Before Using *** How to Use *** Fore Safe Use *** Side Effects

Before Using

In deciding to using a medication, the chance of taking the drug must be weighed against the good it will do. This is a decision you will make. For difenoxin and atropine, the following must be considered

Allergic reaction

Tell your family doctor if you have any unusual or allergy to difenoxin or atropine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy care

Difenoxin and atropine combination has not been studied in pregnant women. However, studies in rats have shown that difenoxin and atropine combination, when given in doses many times the human dose, increases the delivery time and the risk of death of the newborn.

Breast-feeding problem

Both difenoxin and atropine pass into the breast milk. Although it is not known how much of these drugs pass into the breast milk, difenoxin and atropine combination could cause serious effects in the nursing baby. Be sure you have discussed the chance and benefits of this drug with your family doctor.

Use for Children

This drug must not be using in child. Children, especially very young children, are very sensitive to the effects of difenoxin and atropine. This may increase the risk of side effects during treat. Always the fluid loss causing by diarrhea may result in a severe condition. For this reason, it is very important that a sufficient amount of liquids be given to replace the fluid lost by the body. If you have any questions about this, check with your health care professional.

Elderly care

Shortness of breath or difficulty in breathing may be more likely to occur in elderly diseaseds, who are usually more sensitive than adults people to the effects of difenoxin. Always the fluid loss causing by diarrhea may result in a severe condition. For this reason, elderly people must not take this drug without first checking with their family doctor. It is also very important that a sufficient amount of liquids be taken to replace the fluid lost by the body. If you have any questions about this, check with your health care professional.

Drug interactions

Although certain medication must not be using together at all, in other cases two various medication may be using together even if an interaction might occur. In these cases, your family doctor may want to change the dose, or other precautions may be necessary. When you are taking difenoxin and atropine, it is especially important that your health care professional know if you are taking any of the following:

Antibiotics, such as cephalosporins - Ceftin, Keflex, clindamycin - Cleocin, erythromycins - E.E.S., PCE, tetracyclines - Achromycin, Doryx These antibiotics may cause diarrhea. Difenoxin and atropine may make the diarrhea causing by antibiotics worse or make it last longer

Central nervous system - CNS depressants - medication that cause drowsiness Effects, such as drowsiness, of CNS depressants or of difenoxin and atropine may become greater

Monoamine oxidase - MAO inhibitors - furazolidone " Furoxone ", isocarboxazid " Marplan ", phenelzine " Nardil ", procarbazine " Matulane ", tranylcypromine " Parnate " Taking difenoxin and atropine while you are taking or within 2 weeks of taking MAO inhibitors may cause severe side effects; these medication must not be using together

Naltrexone - Trexan Withdrawal side effects may occur in diseaseds who have become addicted to the difenoxin in this combination drug; also, naltrexone will make this drug less effective against diarrhea

Other anticholinergics - drug to help reduce stomach acid and abdominal or stomach spasms or cramps Use of other anticholinergics with this combination drug may increase the effects of the atropine in this combination; however, this is not likely to happen with the usual doses of difenoxin and atropine

Other Information for using

The presence of other medical problems may effect the use of difenoxin and atropine. Make sure you tell your family doctor if you have any other medical problems, especially:

Alcohol abuse - or history of
Drug abuse - history of There is a greater risk that this drug may become habit-forming

Colitis - severe A more serious problem of the colon may develop if you use this drug

Down's syndrome Side effects may be more likely and severe in these diseaseds

Dysentery This condition may get worse; a various kind of treat may be needed

Emphysema, asthma, bronchitis, or other chronic lung disease There is a greater risk that this drug may cause breathing problems in diseaseds who have any of these conditions

Enlarged prostate
Urinary tract blockage or difficult urination Problems with urination may develop with the use of this drug

Gallbladder disease or gallstones Use of this drug may cause spasms of the biliary tract and make the condition worse

Glaucoma Severe pain in the eye may occur with the use of this drug; however, the risk of this happening is low

Heart disease This drug may have some effects on the heart, which may make the condition worse

Hiatal hernia The atropine in this drug may make this condition worse; however, the risk of this happening is low

High blood pressure - hypertension The atropine in this drug may cause an increase in blood pressure; however, the risk of this happening is low

Intestinal blockage This drug may make the condition worse

Kidney disease The atropine in this drug may build up in the body and cause side effects

Liver disease The risk of central nervous system - CNS side effects, including coma, may be greater in diseaseds who have this condition

Myasthenia gravis This drug may make the condition worse

Overactive or underactive thyroid Unwanted effects on breathing and heart rate may occur

Overflow incontinence This drug may make the condition worse