How to Use

Conjugated estrogens and medroxyprogesterone usually come with patient directions. Read them carefully before taking this drug.

Take this drug only as directed by your family doctor. Do not take more of it and do not take it for a longer period of time than your family doctor ordered . The length of time you take the drug will depend on the medical problem for which you are taking conjugated estrogens and medroxyprogesterone. Discuss with your family doctor how long you will need to take these medication.

If you are taking the estrogen or progestin hormones in a certain order - i.e., conjugated estrogens tablets followed by conjugated estrogens and medroxyprogesterone tablets, be sure you know in which order you need to take the medication . If you have questions about this, ask your health care professional.

Nausea may occur during the first few weeks after you start taking estrogens. This effect usually disappears with continued use. If the nausea is bothersome, it can usually be prevented or reduced by taking each dose with food or immediately after food.

Dosage

For conjugated estrogens and conjugated estrogens and medroxyprogesterone
• For oral dosage form - tablets:
  • To prevent loss of bone - osteoporosis or for treating itching or dryness of the genital area - atrophy of the vulva, inflammation of the vagina - atrophic vaginitis, or symptoms of menopause:
    • Adults One tablet - containing 0.625 mg conjugated estrogens once a day on Days 1 through 14; then, one tablet - containing 0.625 mg conjugated estrogens and 5 mg medroxyprogesterone once a day on Days 15 through 28. Repeat cycle.

For conjugated estrogens and medroxyprogesterone
• For oral dosage form - tablets:
  • To prevent loss of bone - osteoporosis or for treating itching or dryness of the genital area - atrophy of the vulva, inflammation of the vagina - atrophic vaginitis, or symptoms of menopause:
    • Adults One tablet - containing 0.3 mg conjugated estrogens and 1.5 mg medroxyprogesterone once a day for twenty-eight days. Repeat cycle. If vaginal bleeding or spotting continues and it is undesired, your family doctor may increase your dose to the next highest strength tablet - 0.45 mg conjugated estrogens and 1.5 mg medroxyprogesterone. It must be taken once a day for twenty-eight days. Repeat cycle.

Missed dose If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage To store this drug:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the drug to break down.
• Do not keep outdated drug or drug no longer needed. Be sure that any discarded drug is out of the reach of children.