Clozapine - Systemic
Brand Names
Clozaril, Leponex
Clozapine *** Before Using *** How to Use *** Fore Safe Use *** Side Effects
Before Using
In deciding to using a medication,
the chance of taking the drug must be weighed against the good it will
do. This is a decision you will make. For clozapine, the following
must be considered
Allergic reaction
Tell your family doctor if you have any unusual or
allergy to clozapine. Also tell your health care professional if
you are allergic to any other substances, such as foods, preservatives, or
dyes.
Pregnancy care
Clozapine has not been studied in pregnant women.
However, clozapine has not been shown to cause birth defects or other problems
in animal studies.
Breast-feeding problem
Clozapine may pass into breast milk and cause drowsiness,
trouble in nursing, restlessness or irritability, convulsions - seizures,
or heart or blood vessel problems in nursing babies.
Use for Children
Studies on this drug have been done only in adult
diseaseds and there is no special info comparing use of clozapine
in child with use in other age groups.
Elderly care
Many medication have not been tested in elderly people.
Therefore, it may not be known whether they work exactly the same way they
do in adults people. Clozapine may be more likely to cause side effects in
the elderly, including dizziness and fainting, low blood pressure and confusion
or excitement.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When you are taking
clozapine, it is especially important that your health care professional know
if you are taking any of the following:
-
Alcohol
-
Central nervous system - CNS depressants - medication that cause drowsiness
-
Tricyclic antidepressants - amitriptyline " Elavil ", amoxapine
" Asendin ", clomipramine " Anafranil ", desipramine " Pertofrane ",
doxepin " Sinequan ", imipramine " Tofranil ", nortriptyline "
Aventyl ", protriptyline " Vivactil ", trimipramine " Surmontil " Using
these medication or alcohol with clozapine may cause increased drowsiness,
low blood pressure, or trouble in breathing
-
Amantadine - Symmetrel
-
Antihypertensives - high blood pressure drug
-
Antipsychotics - drug for mental illness
-
Bromocriptine - Parlodel
-
Certain eye drops using to treat glaucoma - carteolol " Ocupress ",
levobunolol " Betagan ", metipranolol " OptiPranolol ", timolol "
Timoptic "
-
Diuretics - water pills
-
Levodopa - Dopar
-
Medicine for heart disease
-
Nabilone - Cesamet - with high doses
-
Narcotic pain drug
-
Pentamidine - Pentam
-
Pimozide - Orap
-
Promethazine - Phenergan
-
Trimeprazine - Temaril Using these medication with clozapine
may cause low blood pressure, which can cause dizziness or fainting
-
Amphotericin B by injection - Fungizone
-
Antineoplastics - cancer drug
-
Antithyroid agents - drug for overactive thyroid
-
Azathioprine - Imuran
-
Chlorambucil - Leukeran
-
Chloramphenicol - Chloromycetin
-
Colchicine
-
Cyclophosphamide - Cytoxan
-
Flucytosine - Ancobon
-
Ganciclovir - Cytovene
-
Interferon - Intron A, Roferon-A
-
Mercaptopurine - Purinethol
-
Methotrexate - Mexate
-
Plicamycin - Mithracin
-
Zidovudine - AZT, Retrovir Taking clozapine with any
of these medication may increase the risk that very serious blood problems
will occur
-
Lithium Using clozapine with lithium may increase the risk
that convulsions - seizures, confusion or problems with movement will occur
-
Selective serotonin reuptake inhibitors - fluoxetine " Prozac ",
fluvoxamine " Luvox ", paroxetine " Paxil ", sertraline " Zoloft " These
medication can increase the blood levels of clozapine, which increases the
risk that unwanted effects will occur
Other Information for using
The presence of other medical
problems may effect the use of clozapine. Make sure you tell your family doctor if
you have any other medical problems, especially:
-
Blood diseases
-
Enlarged prostate or difficult urination
-
Gastrointestinal problems
-
Glaucoma, narrow angle
-
Heart or blood vessel problems Clozapine may make these conditions
worse
-
Epilepsy or other seizure disorder Clozapine may increase the
risk that seizures will occur
-
Kidney or liver disease Higher blood levels of clozapine may
occur, increasing the risk that unwanted effects will occur
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