Cephalosporins - Systemic
Cephalosporins *** Before Using *** How to Use *** Fore Safe Use *** Side Effects *** Additional Information
Before Using
In deciding to using a medication,
the chance of taking the drug must be weighed against the good it will
do. This is a decision you will make. For the cephalosporins,
the following must be considered
Allergic reaction
Tell your family doctor if you have any unusual or
allergy to any of the cephalosporins, penicillins, penicillin-like
medication, or penicillamine. Also tell your health care professional if you
are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy care
Studies have not been done. However, most
cephalosporins have not been reported to cause birth defects or other problems
in animal studies. Studies in rabbits have shown that cefoxitin may increase
the risk of miscarriages and cause other problems.
Breast-feeding problem
It is not known if cefditoren passes into breast
milk. Most cephalosporins pass into breast milk, usually in small amounts.
However, cephalosporins have not been reported to cause problems in nursing
babies.
Use for Children
Many cephalosporins have been tested in child
and, in effective doses, have not been shown to cause various side effects
or problems than they do in adults. However, there are some cephalosporins
that have not been tested in child up to 12 year of age.
Elderly care
Cephalosporins have been using in the elderly and
they are not expected to cause various side effects or problems in older
people than they do in adults people.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When you are taking
a cephalosporin, it is especially important that your health care professional
know if you are taking any of the following:
-
Alcohol or alcohol-containing drug - cefamandole, cefoperazone,
and cefotetan only Using alcohol and these cephalosporins together
may cause abdominal or stomach cramps, nausea, vomiting, headache, dizziness
or light-headedness, shortness of breath, sweating, or facial flushing; this
reaction usually begins within 15 to 30 minutes after alcohol is consumed
and usually goes away over few hours
-
Aminoglycoside antibiotics, such as
Amikacin - Amikin or
Gentamicin - Apogen or
Neomycin - Mycifradin use with cefuroxime may result in increased
risk of serious side effects
-
Anticoagulants - blood thinners
-
Carbenicillin by injection - Geopen
-
Dipyridamole - Persantine
-
Divalproex - Depakote
-
Heparin - Hepalean, Liquaemin
-
Pentoxifylline - Trental
-
Plicamycin - Mithracin
-
Sulfinpyrazone - Anturane
-
Ticarcillin - Ticar
-
Thrombolytic agents
-
Valproic acid - Depakene Any of these medication may increase
the risk of bleeding, especially when using with cefamandole, cefoperazone,
or cefotetan
-
Diuretics, potent such as
Furosemide - Lasix use with cefuroxime may cause higher blood
levels of cefuroxime and result in increased side effects
-
Iron Iron supplements, including multivitamins that contain
iron, may decrease the effect of cefdinir. However, iron-fortified infant
formula does not decrease the effect of cefdinir
-
Probenecid - Benemid - except cefoperazone, ceftazidime, or
ceftriaxone Probenecid increases the blood level of many cephalosporins.
Although probenecid may be given with a cephalosporin by your family doctor purposely
to increase the blood level to treat some infections, in other cases this
effect may be unwanted and may increase the risk of side effects
Other Information for using
The presence of other medical
problems may effect the use of cephalosporins. Make sure you tell your family doctor
if you have any other medical problems, especially:
-
Bleeding problems, history of - cefamandole, cefditoren, cefoperazone,
and cefotetan only These medication may increase the risk of bleeding
-
Carnitine, low levels Cefditoren may cause carnitine levels
to decrease further.
-
Kidney disease Some cephalosporins need to be given at a lower
dose to people with kidney disease. Always cephalothin and cefuroxime especially,
may increase the risk of kidney damage
-
Liver disease - cefoperazone and cefuroxime Cefoperazone needs
to be given at a lower dose to people with liver disease. Condition may be
worsened by cefuroxime use.
-
Phenylketonuria Cefprozil oral suspension contains phenylalanine
-
Poor nutritional status these may be worsened by cefuroxime
and you may need to have vitamin K
-
Stomach or gastrointestinal disease, history of - especially colitis,
including colitis causing by antibiotics, or enteritis Cephalosporins
may cause colitis in some diseaseds
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