Bortezomib : Before Using

Bortezomib - Systemic

Brand Names

Velcade Bortezomib *** Before Using *** How to Use *** Fore Safe Use *** Side Effects

Before Using

In deciding to using a medication, the problems of uses this drugs must be weighed against the good it will do. This is a decision you will make. For bortezomib, the following must be considered

Allergic reaction

Tell your family doctor if you have any unusual or allergy to bortezomib, boron or mannitol. Also tell your family doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy care

There is a risk that this drug may cause birth defects if it is taken by the mother during pregnancy. Studies in rats and rabbits have shown that bortezomib causes birth defects in the fetus and other problems including miscarriage. However, this drug may be needed in serious diseases or other situations that threaten the mothers life.

Be sure that you have discussed these possible effects with your family doctor before receiving this drug. Before receiving bortezomib make sure your family doctor knows if you are pregnant or if you may become pregnant. It is best to use birth control to prevent pregnancy while you are receiving bortezomib. Tell your family doctor right away if you think you have become pregnant while receiving bortezomib.

Breast-feeding problem

Because bortezomib may cause serious side effects in the breast-fed baby, breast-feeding is generally not recommended while you are receiving this drug.

Use for Children

Studies on this drug have been done only in adult diseaseds and there is no special info comparing use of bortezomib in child with use in other age groups.

Drug interactions

Although certain medication must not be using together at all, in other cases two various medication may be using together even if an interaction might occur. In these cases, your family doctor may want to change the dose, or other precautions may be necessary. When you are taking bortezomib, it is especially important that your family doctor and pharmacist know if you are taking any of the following:

Amiodarone, - Cordarone
Antivirals, - Stavudine
Isoniazid, - e.g.; Nydrazid
Nitrofurantoin, - Macrodantin, Macrobid
Statins - Lipitor, Zocor, Mevacor Use of these medication with bortezomib may increase the risk of peripheral neuropathy - tingling, burning, numbness, or pain in your hands and feet

Antihypertensives - high blood pressure drug May increase the chance of low blood pressure - hypotension

Although certain medication must not be using together at all, in other cases two various medication may be using together even if an interaction might occur. In these cases, your family doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription - over-the-counter "OTC " drug.

Other Information for using

The presence of other medical problems may effect the use of bortezomib. Make sure you tell your family doctor if you have any other medical problems, especially:

Dehydration or
Syncope, history of may cause orthostatic/postural hypotension

Kidney disease
Liver disease Higher blood levels of bortezomib may result and a smaller dose may be needed

Peripheral neuropathy bortezomib may make the symptoms worse or cause new symptoms