Bortezomib - Systemic
Brand Names
Velcade
Bortezomib *** Before Using *** How to Use *** Fore Safe Use *** Side Effects
Before Using
In deciding to using a medication,
the problems of uses this drugs must be weighed against the good it will do.
This is a decision you will make. For bortezomib, the following
must be considered
Allergic reaction
Tell your family doctor if you have any unusual
or allergy to bortezomib, boron or mannitol. Also tell your family doctor
and pharmacist if you are allergic to any other substances, such as foods,
preservatives, or dyes.
Pregnancy care
There is a risk that this drug may cause
birth defects if it is taken by the mother during pregnancy. Studies in rats
and rabbits have shown that bortezomib causes birth defects in the fetus and
other problems including miscarriage. However, this drug may be needed
in serious diseases or other situations that threaten the mothers life. Be sure that you have discussed these possible effects with your family doctor
before receiving this drug. Before receiving bortezomib make sure your
family doctor knows if you are pregnant or if you may become pregnant. It is best
to use birth control to prevent pregnancy while you are receiving bortezomib.
Tell your family doctor right away if you think you have become pregnant while receiving
bortezomib.
Breast-feeding problem
Because bortezomib may cause serious side effects
in the breast-fed baby, breast-feeding is generally not recommended while
you are receiving this drug.
Use for Children
Studies on this drug have been done only in
adult diseaseds and there is no special info comparing use of bortezomib
in child with use in other age groups.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When you are taking
bortezomib, it is especially important that your family doctor and pharmacist know
if you are taking any of the following:
-
Amiodarone, - Cordarone
-
Antivirals, - Stavudine
-
Isoniazid, - e.g.; Nydrazid
-
Nitrofurantoin, - Macrodantin, Macrobid
-
Statins - Lipitor, Zocor, Mevacor Use of these medication
with bortezomib may increase the risk of peripheral neuropathy - tingling,
burning, numbness, or pain in your hands and feet
-
Antihypertensives - high blood pressure drug May increase
the chance of low blood pressure - hypotension
Although certain medication must not be using together at all, in other
cases two various medication may be using together even if an interaction
might occur. In these cases, your family doctor may want to change the dose, or other
precautions may be necessary. Tell your health care professional if you are
taking any other prescription or nonprescription - over-the-counter "OTC "
drug.
Other Information for using
The presence of other medical
problems may effect the use of bortezomib. Make sure you tell your family doctor
if you have any other medical problems, especially:
-
Dehydration or
Syncope, history of may cause orthostatic/postural hypotension
-
Kidney disease
-
Liver disease Higher blood levels of bortezomib may result
and a smaller dose may be needed
-
Peripheral neuropathy bortezomib may make the symptoms worse
or cause new symptoms
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