Antihistamines, Phenothiazine-derivative : Before Using

Antihistamines, Phenothiazine-derivative - Systemic

Antihistamines, Phenothiazine-derivative *** Before Using *** How to Use *** Fore Safe Use *** Side Effects

Before Using

In deciding to using a medication, the chance of taking the drug must be weighed against the good it will do. This is a decision you will make. For phenothiazine-derivative antihistamines, the following must be considered

Allergic reaction

Tell your family doctor if you have any unusual or allergy to these medication or to phenothiazines. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy care

Methdilazine, promethazine and trimeprazine have not been studied in pregnant women. In animal studies, promethazine has not been shown to cause birth defects. However, other phenothiazine medication causing jaundice and muscle tremors in a few newborn babies whose mothers received these medication during pregnancy. Always the newborn baby may have blood clotting problems if promethazine is taken by the mother within 2 weeks before delivery.

Breast-feeding problem

Small amounts of antihistamines pass into the breast milk. Use by nursing mothers is not recommended since babies are more sensitive to the side effects of antihistamines, such as unusual excitement or irritability. Always with the use of phenothiazine-derivative antihistamines there is the risk that the nursing baby may be more at risk of having difficulty in breathing while sleeping or of the sudden infant death syndrome - SIDS. However, more studies are needed to confirm this.

In addition, since these medication tend to decrease the secretions of the body, it is possible that the flow of breast milk may be reduced in some diseaseds.

Use for Children

Serious side effects, such as convulsions - seizures, are more likely to occur in younger diseaseds and would be of greater risk to infants than to older children or adults. In general, children are more sensitive to the effects of antihistamines. Always nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in children The use of phenothiazine-derivative antihistamines is not recommended in child who have a history of difficulty in breathing while sleeping, or a family history of sudden infant death syndrome - SIDS .

Children who show signs of Reye's syndrome must not be given phenothiazine-derivative antihistamines, especially by injection. Uncontrolled movements that may occur with phenothiazine-derivative antihistamines may be mistakenly confusing with symptoms of Reye's syndrome.

Adolescents Adolescents who show signs of Reye's syndrome must not be given phenothiazine-derivative antihistamines, especially by injection. Uncontrolled movements that may occur with phenothiazine-derivative antihistamines may be mistakenly confusing with symptoms of Reye's syndrome.

Elderly care

Elderly diseaseds are especially sensitive to the effects of antihistamines. Confusion; difficult or painful urination; dizziness; drowsiness; feeling faint; or dryness of the mouth, nose, or throat may be more likely to occur in elderly diseaseds. Always nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in elderly diseaseds. In addition, uncontrolled movements may be more likely to occur in elderly diseaseds taking phenothiazine-derivative antihistamines.

Drug interactions

Although certain medication must not be using together at all, in other cases two various medication may be using together even if an interaction might occur. In these cases, your family doctor may want to change the dose, or other precautions may be necessary. When taking phenothiazine-derivative antihistamines, it is especially important that your health care professional know if you are taking/receiving any of the following:

Amoxapine - Asendin
Antipsychotics - drug for mental illness
Methyldopa - Aldomet
Metoclopramide - Reglan
Metyrosine - Demser
Pemoline - Cylert
Pimozide - Orap
Rauwolfia alkaloids - alseroxylon " Rauwiloid ", deserpidine " Harmonyl ", rauwolfia serpentina " Raudixin ", reserpine " Serpasil " Side side effects of medication, such as uncontrolled body movements, may become more severe and frequent if they are using together with phenothiazine-derivative antihistamines

Anticholinergics - drug for abdominal or stomach spasms or cramps Side effects of phenothiazine-derivative antihistamines or anticholinergics, such as dryness of mouth, may be more likely to occur

Central nervous system - CNS depressants - medication that cause drowsiness
Maprotiline
Tricyclic antidepressants - drug for depression Effects of CNS depressants or antihistamines, such as drowsiness, may become more severe; also, taking maprotiline or tricyclic antidepressants may cause some side effects of antihistamines, such as dryness of mouth, to become more severe

Contrast agent, injected into spinal canal If you are having an x-ray test of the head, spinal canal, or nervous system for which you are going to receive an injection into the spinal canal, phenothiazine-derivative antihistamines may increase the risk of seizures; stop taking any phenothiazine-derivative antihistamine 48 hours before the test and do not start taking it until 24 hours after the test

Levodopa When using together with phenothiazine-derivative antihistamines, the levodopa may not work as it must

Monoamine oxidase - MAO inhibitor activity - isocarboxazid " Marplan ", isocarboxazid " Marplan ", phenelzine " Nardil ", procarbazine " Matulane ", selgiline " Eldepryl ", tranylcypromine " Parnate " If you are now taking or have taken within the past 2 weeks any of the MAO inhibitors, the side effects of the phenothiazine-derivative antihistamines may become more severe; these medication must not be using together

Other Information for using

The presence of other medical problems may effect the use of antihistamines. Make sure you tell your family doctor if you have any other medical problems, especially:

Blood disease
Heart or blood vessel disease These medication may cause more serious conditions to develop

Enlarged prostate
Urinary tract blockage or difficult urination Phenothiazine-derivative antihistamines may cause urinary problems to become worse

Epilepsy Phenothiazine-derivative antihistamines, especially promethazine given by injection, may increase the risk of seizures

Glaucoma These medication may cause a slight increase in inner eye pressure that may worsen the condition

Jaundice Phenothiazine-derivative antihistamines may make the condition worse

Liver disease Phenothiazine-derivative antihistamines may build up in the body, which may increase the risk of side effects such as muscle spasms

Reye's syndrome Phenothiazine-derivative antihistamines, especially promethazine given by injection, may increase the risk of uncontrolled movements