Antidiabetic Agents, Sulfonylurea : Before Using

Antidiabetic Agents, Sulfonylurea - Systemic

Antidiabetic Agents, Sulfonylurea *** Before Using *** How to Use *** Fore Safe Use *** Side Effects *** Additional Information

Before Using

In deciding to using a medication, the chance of taking the drug must be weighed against the good it will do. This is a decision you will make. For sulfonylurea medication, the following must be considered

Allergic reaction

Tell your family doctor if you have any unusual or allergy to sulfonylureas, or to sulfonamide-type - sulfa medication, including thiazide diuretics - a certain type of water pill. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy care

Sulfonylureas are rarely using during pregnancy. The amount of insulin you need changes during and after pregnancy. For this reason, it is easier to control your blood sugar using injections of insulin, rather than with the use of sulfonylureas. Close control of your blood sugar can reduce your risk of having high blood sugar during the pregnancy and of your baby gaining too much weight, or having birth defects. Be sure to tell your family doctor if you plan to become pregnant or if you think you are pregnant. If insulin is not available or can't be using and sulfonylureas are using during pregnancy, they must be stopped at least 2 weeks before the delivery date - one month before for chlorpropamide and glipizide. Lowering of blood sugar can occur as a rebound effect at delivery and for few days following birth and will be watched closely by your health care professionals.

Breast-feeding problem

Chlorpropamide and tolbutamide pass into human breast milk and glimepiride passes into the milk of rats. Chlorpropamide and glimepiride are not recommended in nursing mothers but, in some cases, tolbutamide has been using. It is not known if other sulfonylureas pass into breast milk. Check with your family doctor if you are thinking about breast-feeding.

Use for Children

There is little information about the use of sulfonylureas in child. Type 2 diabetes is unusual in this age group.

Elderly care

Some elderly diseaseds may be more sensitive than adults people to the effects of sulfonylureas, especially when more than one antidiabetic drug is being taken or if other medication that effect blood sugar are also being taken. This may increase your risk of developing low blood sugar during treat. Furthermore, the first signs of low or high blood sugar are not easily seen or do not occur at all in older diseaseds. This may increase the risk of low blood sugar developing during treat.

Always elderly diseaseds who take chlorpropamide are more likely to hold too much body water.

Drug interactions

Although certain medication must not be using together at all, in other cases two various medication may be using together even if an interaction might occur. In these cases, your family doctor may want to change the dose, or other precautions may be necessary Do not take any other drug, unless prescribed or approved by your family doctor . When you are taking sulfonylurea antidiabetic drugs, it is especially important that your health care professional know if you are taking any of the following:

Alcohol When low blood sugar occurs, it may last longer than usual if more than a small amount of alcohol is taken, especially on an empty stomach. Small amounts of alcohol at mealtime usually do not cause problems with your blood sugar but may cause a redness - called flushing in the face, arms and neck that can be uncomfortable. This can occur with most of the sulfonylureas but is most likely to occur with chlorpropamide and has occurred up to 12 hours after alcohol was taken during chlorpropamide use

Anticoagulants - blood thinners The effect of either the blood thinner or the antidiabetic drug may be increased or decreased if the two medication are using together

Aspirin or other salicylates
Azole antifungals - miconazole " Monistat I.V. ", fluconazole " Diflucan "
Chloramphenicol - Chloromycetin
Cimetidine - Tagamet
Fluouroquinolones - ciprofloxacin " Cipro ", enoxacin " Penetrex ", lomefloxacin " Maxaquin ", norfloxacin " Noroxin ", ofloxacin " Floxin "
Quinidine - Quinidex
Quinine
Ranitidine - Zantac These medication may increase the chance of low blood sugar

Asparaginase - Elspar
Corticosteroids - cortisone-like drug
Lithium - Lithonate
Thiazide diuretics - Dyazide These medication may increase the chance of high blood sugar

Asthma medication
Cough or cold medication
Hay fever or allergy medication Many medication - including nonprescription "over-the-counter " products can effect the control of your blood sugar

Beta-adrenergic blocking agents - acebutolol " Sectral ", atenolol " Tenormin ", betaxolol " Kerlone ", bisoprolol " Zebeta ", carteolol " Cartrol ", labetalol " Normodyne ", metoprolol " Lopressor ", nadolol " Corgard ", oxprenolol " Trasicor ", penbutolol " Levatol ", pindolol " Visken ", propranolol " Inderal ", sotalol " Betapace ", timolol " Blocadren " Beta-adrenergic blocking agents may increase the risk that high or low blood sugar can occur. Always they can hide symptoms of low blood sugar - such as fast heartbeat. Because of this, a person with diabetes might not recognize that he or she has low blood sugar and might not take immediate steps to treat it. Beta-adrenergic blocking agents can also cause low blood sugar to last longer than usual

Cyclosporine " Sandimmune " Sulfonylureas can increase the effects of cyclosporine

Guanethidine - Ismelin
Monoamine oxidase - MAO inhibitor activity - isocarboxid " Marplan ", isocarboxazid " Marplan ", phenelzine " Nardil ", procarbazine " Matulane ", selegiline " Eldepryl ", or tranylcypromine " Parnate " Taking a sulfonylurea while you are taking - or within 2 weeks of taking these medication may increase the chance of low blood sugar occurring

Octreotide - Sandostatin
Pentamidine - Pentam Use of these medication with sulfonylureas may increase the risk of either high or low blood sugar occurring

Other Information for using

The presence of other medical problems may effect the use of the sulfonylurea antidiabetic medication. Make sure you tell your family doctor if you have any other medical problems, especially:

Acid in the blood - acidosis
Burns - severe
Diabetic coma
Fever, high
Injury, severe
Ketones in the blood - diabetic ketoacidosis
Surgery, major
Any other condition in which insulin needs change rapidly Insulin may be needed temporarily to control diabetes in diseaseds with these conditions because changes in blood sugar may occur rapidly and without much warning; also, your blood sugar may need to be tested more often

Diarrhea, continuing
Female hormone changes for some women - during puberty, pregnancy, or menstruation
Infection, severe
Mental stress, severe
Overactive adrenal gland, not properly controlled
Problems with intestines, severe
Slow stomach emptying
Vomiting, continuing
Any other condition that causes severe blood sugar changes Insulin may be needed temporarily to control diabetes mellitus in diseaseds with these conditions because changes in blood sugar may occur rapidly and without much warning; also, your blood sugar may need to be tested more often

Heart disease Chlorpropamide or tolbutamide causes some diseaseds to retain - keep more body water than usual. Heart disease may be worsened by this extra body water

Kidney disease
Liver disease Your blood sugar may be increased or decreased, partly because of slower removal of sulfonylurea from the body; this may change the amount of sulfonylurea you need

Overactive thyroid, not properly controlled
Underactive thyroid, not properly controlled Your blood sugar may be increased or decreased, partly because the drug may be removed from the body too fast or too slow. Until your thyroid condition is controlled, the amount of sulfonylurea you need may change. Always your blood sugar may need to be tested more often

Underactive adrenal gland, not properly controlled
Underactive pituitary gland, not properly controlled
Undernourished condition
Weakened physical condition
Any other condition that causes low blood sugar Patients with these conditions may be more likely to develop low blood sugar while taking sulfonylureas