Anti-inflammatory Drugs, Nonsteroidal - Systemic
Anti-inflammatory Drugs, Nonsteroidal *** Before Using *** How to Use *** Fore Safe Use *** Side Effects
Before Using
In deciding to using a medication,
the chance of taking the drug must be weighed against the good it will
do. This is a decision you and your health care professional will make. For
the nonsteroidal anti-inflammatory drugs, the following must be considered
Allergic reaction
Tell your health care professional if you have ever
had any unusual or allergy to any of the nonsteroidal anti-inflammatory
drugs, or to any of the following medication:
-
Aspirin or other salicylates
-
Ketorolac - Toradol
-
Oxyphenbutazone - Oxalid, Tandearil
-
Suprofen - Suprol
-
Zomepirac - Zomax
Also tell your health care professional if you are allergic to any other
substances, such as foods, preservatives, or dyes.
Diet Make certain your health care professional
knows if you are on any special diet, such as a low-sodium or low-sugar diet.
Some of these medication contain sodium or sugar.
Pregnancy care
Studies on birth defects with these medication have
not been done. However, there is a risk that these medication may
cause unwanted effects on the heart or blood flow of the fetus or newborn
baby if they are taken regularly during the last few months of pregnancy.
Always studies in pets have shown that these medication, if taken late in
pregnancy, may increase the length of pregnancy, prolong labor, or cause other
problems during delivery. If you are pregnant, do not take any of these medication,
including nonprescription - over-the-counter "OTC " ibuprofen or naproxen,
without first discussing its use with your family doctor.Studies in pets have not shown that fenoprofen, floctafenine, flurbiprofen,
ibuprofen, ketoprofen, nabumetone, naproxen, phenylbutazone, piroxicam, tiaprofenic
acid, or tolmetin causes birth defects. Diflunisal causing birth defects of
the spine and ribs in rabbits, but not in mice or rats. Diclofenac and meclofenamate
causing unwanted effects on the formation of bones in pets. Etodolac and
oxaprozin causing birth defects in pets. Indomethacin causing slower development
of bones and damage to nerves in pets. In some animal studies, sulindac
causing unwanted effects on the development of bones and organs. Studies on
birth defects with mefenamic acid have not been done in pets.
Even though most of these medication did not cause birth defects in pets,
many of them did cause other harmful or toxic effects on the fetus, usually
when they were given in such large amounts that the pregnant pets became
sick.
Breast-feeding problem
-
For indomethacin
: Indomethacin passes
into the breast milk and has been reported to cause unwanted effects in nursing
babies.
-
For meclofenamate
: Use of meclofenamate
by nursing mothers is not recommended, because in animal studies it causing
unwanted effects on the newborn's development.
-
For phenylbutazone
: Phenylbutazone passes
into the breast milk and may cause unwanted effects, such as blood problems,
in nursing babies.
-
For piroxicam
: Studies in pets have
shown that piroxicam may decrease the amount of milk.
Although other anti-inflammatory analgesics have not been
reported to cause problems in nursing babies, diclofenac, diflunisal, fenoprofen,
flurbiprofen, meclofenamate, mefenamic acid, naproxen, piroxicam and tolmetin
pass into the breast milk. It is not known whether etodolac, floctafenine,
ibuprofen, ketoprofen, nabumetone, oxaprozin, sulindac, or tiaprofenic acid
passes into human breast milk.
Use for Children
-
For ibuprofen
: Ibuprofen has been tested
in child 6 months of age and older. It has not been shown to cause various
side effects or problems than it does in adults.
-
For indomethacin and for tolmetin
: Indomethacin
and tolmetin have been tested in child 2 years of age and older and have
not been shown to cause various side effects or problems than they do in
adults.
-
For naproxen
: Studies with naproxen in
children 2 years of age and older have shown that skin rash may be more likely
to occur.
-
For oxaprozin
: Oxaprozin has been using
in child with arthritis. However, there is no special info comparing
use of this drug in child with use in other age groups.
-
For phenylbutazone
: Use of phenylbutazone
in child up to 15 years of age is not recommended.
-
For other anti-inflammatory analgesics
:
There is no special info on the use of other anti-inflammatory analgesics
in child.
Most of these medication, especially indomethacin and phenylbutazone,
can cause serious side effects in any patient. Therefore, it is especially
important that you discuss with the child's family doctor the good that this drug
may do as well as the chance of using it.
Elderly care
Certain side effects, such as confusion, swelling
of the face, feet, or lower legs, or sudden decrease in the amount of urine,
may be especially likely to occur in elderly diseaseds, who are usually more
sensitive than adults people to the effects of nonsteroidal anti-inflammatory
drugs. Always elderly people are more likely than adults people to get very
sick if these medication cause stomach problems. With phenylbutazone, blood
problems may also be more likely to occur in the elderly.
Drug interactions
Although certain medication must not be using
together at all, in other cases two various medication may be using together
even if an interaction might occur. In these cases, your family doctor may want to
change the dose, or other precautions may be necessary. When you are taking
a nonsteroidal anti-inflammatory drug, it is especially important that your
health care professional know if you are taking any of the following:
-
Anticoagulants - blood thinners
-
Cefamandole - Mandol
-
Cefoperazone - Cefobid
-
Cefotetan - Cefotan
-
Heparin
-
Plicamycin - Mithracin
-
Valproic acid The risk of bleeding may be increased
-
Aspirin The risk of serious side effects may be increased
if aspirin is using together with a nonsteroidal anti-inflammatory drug on
a regular basis
-
Ciprofloxacin - Cipro
-
Enoxacin - Penetrex
-
Itraconazole - Sporanox
-
Ketoconazole - Nizoral
-
Lomefloxacin - Maxaquin
-
Norfloxacin - Noroxin
-
Ofloxacin - Floxin
-
Tetracyclines, oral The buffered form of phenylbutazone -
Alka Butazolidin may keep these medication from help you if the 2
medication are taken too close together
-
Cyclosporine - Sandimmune
-
Digitalis glycosides - heart drug
-
Lithium - Lithane
-
Methotrexate - Mexate
-
Phenytoin - Dilantin Higher blood levels of these medication
and an increased risk of side effects may occur
-
Penicillamine - Cuprimine The risk of serious side
effects may be increased, especially with phenylbutazone - Cotylbutazone
-
Probenecid - Benemid Higher blood levels of the nonsteroidal
anti-inflammatory drug and an increased risk of side effects may occur
-
Triamterene - Dyrenium The risk of kidney problems
may be increased, especially with indomethacin
-
Zidovudine - AZT, Retrovir The risk of serious side
effects may be increased, especially with indomethacin
Other Information for using
The presence of other medical
problems may effect the use of nonsteroidal anti-inflammatory drugs. Make
sure you tell your family doctor if you have any other medical problems, especially:
-
Alcohol abuse
-
Bleeding problems
-
Colitis, Crohn's disease, diverticulitis, stomach ulcer, or other
stomach or intestinal problems
-
Diabetes mellitus - sugar diabetes
-
Hemorrhoids
-
Hepatitis or other liver disease
-
Kidney disease - or history of
-
Rectal irritation or bleeding, recent,
-
Systemic lupus erythematosus - SLE
-
Tobacco use - or recent history of The risk of side effects
may be increased
-
Anemia
-
Asthma
-
Epilepsy
-
Fluid retention - swelling of feet or lower legs
-
Heart disease
-
High blood pressure
-
Kidney stones - or history of
-
Low platelet count
-
Low white blood cell count
-
Mental illness
-
Parkinson's disease
-
Polymyalgia rheumatica
-
Porphyria
-
Temporal arteritis Some nonsteroidal anti-inflammatory drugs
may make these conditions worse
-
Ulcers, sores, or white spots in mouth Ulcers, sores, or white
spots in the mouth sometimes mean that the drug is causing serious side
effects; if these sores or spots are already present before you start taking
the drug, it will be harder for you and your family doctor to recognize that
these side effects might be occurring
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