Amprenavir : Before Using

Amprenavir - Systemic

Brand Names

Agenerase Amprenavir *** Before Using *** How to Use *** Fore Safe Use *** Side Effects

Before Using

In deciding to using a medication, the chance of taking the drug must be weighed against the good it will do. This is a decision you will make. For amprenavir, the following must be considered

Allergic reaction

Tell your family doctor if you have any unusual or allergy to amprenavir or sulfa medication. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy care

Amprenavir has not been studied in pregnant women. However, studies in pets have shown that amprenavir causes birth defects and other problems. Amprenavir capsules must only be using during pregnancy if the benefit outweighs the potential risk. Amprenavir oral solution must only be using during pregnancy if the benefit outweighs the potential risk. Before taking this drug, make sure your family doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding problem

It is not known whether amprenavir passes into breast milk. However, breast-feeding is not recommended in diseaseds with HIV-infection because of the risk of passing the HIV virus on to the nursing infant. Mothers must not breast-feed while taking amprenavir.

Use for Children

This drug has been tested in child 4 years of age and older. In effective doses, the drug has not been shown to cause various side effects or problems than it does in adults.

Elderly care

Many medication have not been studied specifically in elderly people. Therefore, it may not be known whether they work exactly the same way they do in adults people or if they cause various side effects or problems in elderly people. However, specific side effects may be especially likely to occur in elderly diseaseds, who are usually more sensitive than younger adults to the effects of amprenavir. There is no special info comparing use of amprenavir in the elderly with use in other age groups.

Drug interactions

Although certain medication must not be using together at all, in other cases two various medication may be using together even if an interaction might occur. In these cases, your family doctor may want to change the dose, or other precautions may be necessary. When you are taking amprenavir, it is especially important that your health care professional know if you are taking any other medication - prescription or over-the-counter "OTC ", especially the following:

Alcohol the ingredients in amprenavir oral solution must not be mixed with alcohol. Do not use together.

Amiodarone
Lidocaine - systemic
Quinidine
Tricyclic antidepressants - amitriptyline " Elavil ", amoxapine " Asendin ", clomipramine " Anafranil ", desipramine " Norpramin ", doxepin " Sinequan ", imipramine " Tofranil ", nortriptyline " Aventyl, Pamelor ", protriptyline " Vivactil ", trimipramine " Surmontil " There is a possibility that amprenavir may interfere with the removal of these medication from the body, which could lead to serious side effects

Antacids
Didanosine - Videx Use of antacids or didanosine with amprenavir may keep amprenavir from help you if taken close together. Antacids and didanosine must be taken at least one hour before or after amprenavir.

Bepridil - e.g. Vascor Use of bepridil and amprenavir together can cause life-threatening reactions. Use together with caution.

Carbamazepine - Tegretol
Phenobarbital
Phenytoin - Dilantin Use of these medication with amprenavir may cause amprenavir to be less effective. Use with caution.

Cyclosporine - Sandimmune
Rapamycin - Rapamune
Tacrolimus - Prograf Use with amprenavir may cause more side effects

Cisapride - Propulsid Do not use with amprenavir as life-threatening reactions can occur.

Delavirdine - Rescriptor Use with amprenavir may lead to a possible resistance to delavirdine. They must not be aplaying together.

Disulfiram - Antabuse
Metronidazole - Flagyl Use of these medication with amprenavir oral solution can be dangerous. Do not use together.

Ergot derivatives - D.H.E., Methergine, Ergotrate Use of these medication with amprenavir can cause serious side effects. Do not use together.

Itraconazole - Sporanox
Ketoconazole - Nizoral The dose of these medication may need to be lowered.

HMG-CoA reductase inhibitors - atorvastatin " Lipitor ", lovastatin " Mevacor ", simvastatin " Zocor " Use of amprenavir may cause a high blood level of these medication. If you are on atorvastatin while on amprenavir, use the lowest possible dose or consider using other HMG-CoA reductase inhibitors.

Midazolam - Versed
Triazolam - Halcion Use of these medication with amprenavir can cause serious reactions and must not be using together.

Oral contraceptives Use of these medication may cause amprenavir to be less effective. Alternate methods of birth control are recommended.

Pimozide - Orap Use of this drug with amprenavir can cause serious reactions. Do not use together.

Rifabutin - Mycobutin Use of amprenavir can cause increased blood levels of rifabutin. Rifabutin can cause decreased blood levels of amprenavir.

Rifampin Use of this drug may lead to possible resistance to amprenavir. Do not use together.

Ritonavir capsules - Norvir Using this drug with amprenavir can cause an increase in the amount of amprenavir your body gets.

Ritonavir oral solution Amprenavir and ritonavir oral solution may remain in your body for longer periods of time. Use of these medication together is not recommended.

Saquinavir - Forovase, Invirase Amprenavir levels may be decreased.

Sildenafil - Viagra Use of this drug with amprenavir may increase the amount of sildenafil in the body and may increase the risk for side effects, such as low blood pressure, changes in vision and erection of the penis lasting more than 4 hours. Use a reduced dose of sildenafil.

St. John's wort This drug can decrease the blood levels of amprenavir in your body. It may also result in resistance to amprenavir.

Warfarin - Coumadin Amprenavir may decrease your blood clotting time and make you bleed more easily.

Other Information for using

The presence of other medical problems may effect the use of amprenavir. Make sure you tell your family doctor if you have any other medical problems, especially:

Diabetes mellitus
Hemophilia Amprenavir may make these conditions worse

Kidney failure
Liver failure Amprenavir oral solution must not be using because serious side effects may occur

Liver disease Effects of amprenavir may be increased because of slower removal of amprenavir from the body

Vitamin K deficiency The high amounts of vitamin E in amprenavir dosage forms may increase the risk of bleeding problems in diseaseds who are deficient in vitamin K